PIM3

Gene Symbol PIM3
Entrez Gene 415116
Alt Symbol pim-3
Species Human
Gene Type protein-coding
Description Pim-3 proto-oncogene, serine/threonine kinase
Other Description pim-3 oncogene|serine/threonine kinase Pim-3|serine/threonine-protein kinase pim-3
Swissprots B1B0P0 Q68BM2 A5D8X8 Q86V86 A8K7J0
Accessions EAW73485 Q86V86 AB114795 BAD42438 AK292005 BAF84694 BC017083 BC052239 BC064477 AAH64477 BC140030 AAI40031 BC141855 AAI41856 CT000425 DB482257 NM_001001852 NP_001001852
Function Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth. {ECO:0000269|PubMed:15540201, ECO:0000269|PubMed:16818649, ECO:0000269|PubMed:17270021, ECO:0000269|PubMed:17876606, ECO:0000269|PubMed:18593906}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:17876606}.
Tissue Specificity Detected in various tissues, including the heart, brain, lung, kidney, spleen, placenta, skeletal muscle, and peripheral blood leukocytes. Not found or barely expressed in the normal adult endoderm-derived organs such as colon, thymus, liver, or small intestine. However, expression is augmented in premalignant and malignant lesions of these organs. {ECO:0000269|PubMed:15540201, ECO:0000269|PubMed:16818649, ECO:0000269|PubMed:17270021}.

Pim-3 (D17C9) Rabbit mAb - 4165 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D17C9
Western blot analysis of extracts from various cell lines using Pim-3 (D17C9) Rabbit mAb.

Pim-3 (H-40) - sc-98959 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Pim-3 (H-40): sc-98959. Western blot analysis of Pim-3 expression in LNCaP whole cell lysate.

Pim-3 (C-18) - sc-49485 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Pim-3 (P-16) - sc-49488 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PIM3 antibody - ab108920 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PIM3 antibody (ab108920) at 1 µg/mlLane 1 : Heart (Human) Tissue Lysate - adult normal tissue (ab29431)Lane 2 : Heart (Human) Tissue Lysate - adult normal tissue (ab29431) with Immunizing peptide at 1 µg/mlLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-PIM3 antibody - C-terminal - ab198842 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human brain tissue labeling PIM3 using ab198842 at 1/20

Anti-PIM3 antibody - Carboxyterminal end - ab71321 from Abcam

Prices $313.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin fixed and paraffin embedded human hepatocarcinoma tissue reacted with PIM3 antibody (C-term) using ab71321 at 1/50. ab71321 was peroxidase conjugated to the secondary antibody, followed by DAB staining.

Anti-PIM3 / PIM-3 Antibody (C-Terminus, AP) - LS-C280963 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIM3 / PIM-3 Antibody (C-Terminus, APC) - LS-C280964 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIM3 / PIM-3 Antibody (C-Terminus, Biotin) - LS-C280965 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIM3 / PIM-3 Antibody (C-Terminus, FITC) - LS-C280966 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIM3 / PIM-3 Antibody (C-Terminus, Azide-free, HRP) - LS-C280967 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIM3 / PIM-3 Antibody (C-Terminus, PE) - LS-C280968 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIM3 / PIM-3 Antibody (C-Terminus) - LS-C330587 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIM3 / PIM-3 Antibody (aa259-288) IHC-plus™ - LS-B3461 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PIM3 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3461 concentration 10 ug/ml.

PIM3 Antibody - NBP1-50553 from Novus Biologicals

Prices $329.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: PIM3 Antibody [NBP1-50553] - Analysis of anti-PIM3 antibody with mouse kidney tissue lysate.

ANTI-PIM3(C-TERMINAL) antibody produced in rabbit - SAB1307112 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PIM3 (C-term): <B>Cat. No. SAB1307112</B>: Formalin-fixed and paraffin-embedded Human hepatocarcinoma tissue reacted with PIM3 Antibody (C-term),which was peroxidase-conjuGoated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this for immunohistochemistry; clinical relevance has not been evaluated.

Anti-PIM3 (C-term) antibody produced in rabbit - SAB1300013 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PIM3 (C-term) Antibody: <B>Cat. No. SAB1300013</B>: PIM3 in human hepatocarcinoma tissue with Anti-PIM3 (C-term) Antibody at 40 μg/mL.

Monoclonal Anti-PIM3, (C-terminal) antibody produced in mouse - SAB1403508 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4A9
<B>Immunoblotting</B><BR/>Monoclonal Anti-PIM3: <B>Cat. No. SAB1403508</B>: Antibody concentration: 1 μg/mL. Specific band of ~35.5 kDa using immunogen protein lysate.

PIM3-Antibody-C-term - AP7171a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
The anti-PIM3 Pab (Cat. #AP7171a) is used in Western blot to detect PIM3 in mouse kidney tissue lysate.

PIM3 Antibody - C-terminal region (OAAB16941) - OAAB16941 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

PIM3 Antibody (OALA03358) - OALA03358 from Aviva Systems Biology

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

PIM3 (C-term) antibody - AP13824PU-N from Acris Antibodies

Prices $330.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with PIM3 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

PIM3 (C-term) antibody - AP22788PU-N from Acris Antibodies

Prices $430.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Spleen (formalin-fixed, paraffin-embedded) stained with PIM3 antibody AP22788PU-N followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

PIM3 antibody - H00415116-M10 from Acris Antibodies

Prices $360.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4A9
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