| Gene Symbol |
PIM3
|
| Entrez Gene |
415116
|
| Alt Symbol |
pim-3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Pim-3 proto-oncogene, serine/threonine kinase
|
| Other Description |
pim-3 oncogene|serine/threonine kinase Pim-3|serine/threonine-protein kinase pim-3
|
| Swissprots |
B1B0P0 Q68BM2 A5D8X8 Q86V86 A8K7J0
|
| Accessions |
EAW73485 Q86V86 AB114795 BAD42438 AK292005 BAF84694 BC017083 BC052239 BC064477 AAH64477 BC140030 AAI40031 BC141855 AAI41856 CT000425 DB482257 NM_001001852 NP_001001852
|
| Function |
Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth. {ECO:0000269|PubMed:15540201, ECO:0000269|PubMed:16818649, ECO:0000269|PubMed:17270021, ECO:0000269|PubMed:17876606, ECO:0000269|PubMed:18593906}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:17876606}.
|
| Tissue Specificity |
Detected in various tissues, including the heart, brain, lung, kidney, spleen, placenta, skeletal muscle, and peripheral blood leukocytes. Not found or barely expressed in the normal adult endoderm-derived organs such as colon, thymus, liver, or small intestine. However, expression is augmented in premalignant and malignant lesions of these organs. {ECO:0000269|PubMed:15540201, ECO:0000269|PubMed:16818649, ECO:0000269|PubMed:17270021}.
|