PIM3

Gene Symbol	PIM3
Entrez Gene	415116
Alt Symbol	pim-3
Species	Human
Gene Type	protein-coding
Description	Pim-3 proto-oncogene, serine/threonine kinase
Other Description	pim-3 oncogene|serine/threonine kinase Pim-3|serine/threonine-protein kinase pim-3
Swissprots	B1B0P0 Q68BM2 A5D8X8 Q86V86 A8K7J0
Accessions	EAW73485 Q86V86 AB114795 BAD42438 AK292005 BAF84694 BC017083 BC052239 BC064477 AAH64477 BC140030 AAI40031 BC141855 AAI41856 CT000425 DB482257 NM_001001852 NP_001001852
Function	Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth. {ECO:0000269|PubMed:15540201, ECO:0000269|PubMed:16818649, ECO:0000269|PubMed:17270021, ECO:0000269|PubMed:17876606, ECO:0000269|PubMed:18593906}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17876606}.
Tissue Specificity	Detected in various tissues, including the heart, brain, lung, kidney, spleen, placenta, skeletal muscle, and peripheral blood leukocytes. Not found or barely expressed in the normal adult endoderm-derived organs such as colon, thymus, liver, or small intestine. However, expression is augmented in premalignant and malignant lesions of these organs. {ECO:0000269|PubMed:15540201, ECO:0000269|PubMed:16818649, ECO:0000269|PubMed:17270021}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PIM3 / PIM-3 ELISA Kit (Sandwich ELISA) - LS-F7735 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 0.228 ng/ml Range 0.625-40 ng/ml

Human PIM3 / PIM-3 ELISA Kit (Sandwich ELISA) - LS-F12334 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.625-40 ng/ml

Human Pim-3 Oncogene ELISA Kit - abx152746 from Abbexa Category ELISA Kit Sensitivity 0.228 ng/ml Range 0.625 ng/ml - 40 ng/ml

Pim-3 Oncogene (PIM3), Human, ELISA Kit - SEN637Hu from ARP American Research Products Category ELISA Kit Prices $790.00 Sizes 96 t Sensitivity 0.228ng/mL Range 0.625-40ng/mL

Serine/threonine-protein kinase pim-3, PIM3, Human, ELISA Kit - E4599h from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t Range 0.156-10 ng/mL

Pim-3 Oncogene (PIM3), Human, CLIA Kit - SCN637Hu from ARP American Research Products Category CLIA Kit Prices $840.00 Sizes 96 t Sensitivity 0.276ng/mL Range 0.625-40ng/mL

Pim-3 Oncogene, ELISA Kit - MBS070422 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-3 Oncogene, ELISA Kit - MBS102443 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-3 Oncogene, ELISA Kit - MBS094367 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-3 Oncogene, ELISA Kit - MBS062114 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-3 Oncogene, ELISA Kit - MBS072889 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-3 Oncogene, ELISA Kit - MBS065739 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-3 Oncogene, ELISA Kit - MBS071927 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

pim-3 oncogene, ELISA Kit - MBS9337079 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-3 Oncogene (PIM3), ELISA Kit - MBS2020407 from MyBioSource Category ELISA Kit Prices $410.00, $610.00, $830.00, $3,420.00, $6,200.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.228ng/mL. Range 0.625-40ng/mL

ELISA Kit for Pim-3 Oncogene (PIM3) - SEN637Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.228ng/mL. Range 0.625-40ng/mL The standard curve concentrations used for the ELISA’s were 40ng/mL, 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL

CLIA Kit for Pim-3 Oncogene (PIM3) - SCN637Hu from Uscn Life Science Inc. Category CLIA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.03ng/mL. Range 0.055-40ng/mL The standard curve concentrations used for the CLIA’s were 40ng/mL, 13.333ng/mL, 4.444ng/mL, 1.481ng/mL, 0.494ng/mL, 0.165ng/mL, 0.055ng/mL

ELISA Kit for Pim-3 Oncogene (PIM3) - SEN637Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.228ng/mL. Range 0.625-40ng/mL The standard curve concentrations used for the ELISA's were 40ng/mL, 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL

CLIA Kit for Pim-3 Oncogene (PIM3) - SCN637Hu from Cloud-clone Category CLIA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.03ng/mL. Range 0.055-40ng/mL The standard curve concentrations used for the ELISA's were 40ng/mL, 13.33ng/mL, 4.44ng/mL, 1.48ng/mL, 0.494ng/mL, 0.165ng/mL, 0.055ng/mL

Mouse PIM3 / PIM-3 ELISA Kit (Custom ELISA) - LS-F19934 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.625-40 ng/ml

Rat PIM3 / PIM-3 ELISA Kit (Custom ELISA) - LS-F19933 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.625-40 ng/ml

Human Pim-3 Oncogene (PIM3) ELISA Kit - EKU06643 from Biomatik Category ELISA Kit Prices $809.00, $3,557.00, $6,468.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.239 ng/mL Range 0.625-40 ng/mL

Human Pim-3 Oncogene CLIA Kit - abx190020 from Abbexa Category CLIA Kit Range 0.055 ng/ml - 40 ng/ml

Pim-3 Oncogene (PIM3), Human, ELISA Kit - DL-PIM3-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.625-40 ng/mL

Pim-3 Oncogene (PIM3), CLIA Kit - MBS2001144 from MyBioSource Category CLIA Kit Prices $440.00, $655.00, $900.00, $3,705.00, $6,680.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.276 ng/mL Range 0.625-40 ng/mL

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