PIM3

Gene Symbol	PIM3
Entrez Gene	415116
Alt Symbol	pim-3
Species	Human
Gene Type	protein-coding
Description	Pim-3 proto-oncogene, serine/threonine kinase
Other Description	pim-3 oncogene|serine/threonine kinase Pim-3|serine/threonine-protein kinase pim-3
Swissprots	B1B0P0 Q68BM2 A5D8X8 Q86V86 A8K7J0
Accessions	EAW73485 Q86V86 AB114795 BAD42438 AK292005 BAF84694 BC017083 BC052239 BC064477 AAH64477 BC140030 AAI40031 BC141855 AAI41856 CT000425 DB482257 NM_001001852 NP_001001852
Function	Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth. {ECO:0000269|PubMed:15540201, ECO:0000269|PubMed:16818649, ECO:0000269|PubMed:17270021, ECO:0000269|PubMed:17876606, ECO:0000269|PubMed:18593906}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17876606}.
Tissue Specificity	Detected in various tissues, including the heart, brain, lung, kidney, spleen, placenta, skeletal muscle, and peripheral blood leukocytes. Not found or barely expressed in the normal adult endoderm-derived organs such as colon, thymus, liver, or small intestine. However, expression is augmented in premalignant and malignant lesions of these organs. {ECO:0000269|PubMed:15540201, ECO:0000269|PubMed:16818649, ECO:0000269|PubMed:17270021}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active mouse PIM3 full length protein - ab125561 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Mouse

Human PIM3 protein fragment - ab153649 from Abcam Category Protein Source Wheat germ Species Human

PIM3 / PIM-3 Antibody Blocking Peptide - LS-E8738 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PIM3 Protein - H00415116-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PIM3-Antibody-C-term-Blocking-Peptide - BP7171a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIM3 - H00415116-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PIM3 - H00415116-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PIM3 - P5623 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

PIM3 fusion protein - Ag17859 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PIM3 fusion protein - ag17748 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Pim-3, His-tagged - Pim3-116H from Creative Biomart Category Protein Source Sf21 insect cells Species Human

Recombinant Pim-3 Oncogene (PIM3) - RPN637Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Pim-3 Protein, active, 10 µg - 14-738 from EMD Millipore Category Protein Prices $401.00 Sizes 10 µg Source expressed by baculovirus in Sf21 cells

Recombinant Pim-3 Oncogene (PIM3) - RPN637Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Serine/threonine-protein kinase pim-3(PIM3) - CSB-YP771444HU CSB-EP771444HU CSB-BP771444HU CSB-MP771444HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Active human PIM3 full length protein - ab204146 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

PIM3 - TP312690 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Pim-3 Protein, active, 250 µg - 14-738M from EMD Millipore Category Protein Prices $2,543.00 Sizes 250 µg also available in 10 μg size . (cat#14-738) and in bulk (cat# 14-738-K) Source expressed by baculovirus in Sf21 cells

PIM3 Peptide, Human - M34GP11799H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Pim-3 Oncogene (PIM3) - RPU51923 from Biomatik Category Protein Prices $180.00, $369.00, $564.00, $672.40 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

PIM3 Recombinant Protein (OPCD00865) - OPCD00865 from Aviva Systems Biology Category Protein Source E.coli Species Human

PIM3 Recombinant Protein Antigen - NBP2-55816PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Pim-3 Oncogene, Recombinant Protein - MBS2033173 from MyBioSource Category Protein Prices $175.00, $370.00, $575.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Serine/threonine-protein kinase pim-3 (PIM3), Recombinant Protein - MBS1458171 from MyBioSource Category Protein Prices $1,085.00, $1,085.00, $1,315.00, $1,315.00, $1,710.00, $1,710.00, $2,170.00, $2,170.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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