| Gene Symbol |
AWAT1
|
| Entrez Gene |
158833
|
| Alt Symbol |
DGA2, DGAT2L3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
acyl-CoA wax alcohol acyltransferase 1
|
| Other Description |
diacyl-glycerol acyltransferase 2|diacylglycerol O-acyltransferase 2-like 3|diacylglycerol O-acyltransferase 2-like protein 3|diacylglycerol acyltransferase 2|long-chain-alcohol O-fatty-acyltransferase 1
|
| Swissprots |
Q58HT5 Q5JT21 Q6IEE4
|
| Accessions |
EAX05353 Q58HT5 AY947638 AAX48018 BC039181 BC146428 AAI46429 BC153034 AAI53035 BN000155 CAD89266 W68831 NM_001013579 NP_001013597
|
| Function |
Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20). {ECO:0000269|PubMed:15671038}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Predominantly expressed in skin, where it is limited to the sebaceous gland. Expressed in more mature, centrally located cells just before their rupture and sebum release. Also expressed in all tissues except spleen. Expressed at higher level in thymus, prostate and testis. {ECO:0000269|PubMed:15671038}.
|
![Western Blot: AWAT1 Overexpression Lysate (Adult Normal) [NBL1-09846] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AWAT1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4976_AWAT1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09846-img0002.jpg)