AWAT1
| Gene Symbol | AWAT1 |
|---|---|
| Entrez Gene | 158833 |
| Alt Symbol | DGA2, DGAT2L3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | acyl-CoA wax alcohol acyltransferase 1 |
| Other Description | diacyl-glycerol acyltransferase 2|diacylglycerol O-acyltransferase 2-like 3|diacylglycerol O-acyltransferase 2-like protein 3|diacylglycerol acyltransferase 2|long-chain-alcohol O-fatty-acyltransferase 1 |
| Swissprots | Q58HT5 Q5JT21 Q6IEE4 |
| Accessions | EAX05353 Q58HT5 AY947638 AAX48018 BC039181 BC146428 AAI46429 BC153034 AAI53035 BN000155 CAD89266 W68831 NM_001013579 NP_001013597 |
| Function | Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20). {ECO:0000269|PubMed:15671038}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Predominantly expressed in skin, where it is limited to the sebaceous gland. Expressed in more mature, centrally located cells just before their rupture and sebum release. Also expressed in all tissues except spleen. Expressed at higher level in thymus, prostate and testis. {ECO:0000269|PubMed:15671038}. |
Human DGAT2L3 full length protein - ab165711 from Abcam
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AWAT1 / DGAT2L3 Antibody Blocking Peptide - LS-E16403 from LifeSpan Bioscience
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AWAT1 / DGAT2L3 Antibody Blocking Peptide - LS-E16404 from LifeSpan Bioscience
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Recombinant Human AWAT1 Protein - H00158833-P01 from Novus Biologicals
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AWAT1 Blocking Peptide - 33R-5195 from Fitzgerald
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AWAT1 Blocking Peptide - 33R-6931 from Fitzgerald
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DGAT2L3 / AWAT1 - H00158833-P01 from Acris Antibodies
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AWAT1 fusion protein - ag20183 from Proteintech Group
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Recombinant Human AWAT1 - AWAT1-1292H from Creative Biomart
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DGAT2L3 Blocking Peptide - CBP4343 from Cohesion Biosciences
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DGAT2L3 Blocking Peptide - abx161554 from Abbexa
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AWAT1 Recombinant Protein Antigen - NBP2-49395PEP from Novus Biologicals
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AWAT1 Peptide, Human - M34GP01244H from Creative Peptides
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