Gene Symbol | AWAT1 |
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Entrez Gene | 158833 |
Alt Symbol | DGA2, DGAT2L3 |
Species | Human |
Gene Type | protein-coding |
Description | acyl-CoA wax alcohol acyltransferase 1 |
Other Description | diacyl-glycerol acyltransferase 2|diacylglycerol O-acyltransferase 2-like 3|diacylglycerol O-acyltransferase 2-like protein 3|diacylglycerol acyltransferase 2|long-chain-alcohol O-fatty-acyltransferase 1 |
Swissprots | Q58HT5 Q5JT21 Q6IEE4 |
Accessions | EAX05353 Q58HT5 AY947638 AAX48018 BC039181 BC146428 AAI46429 BC153034 AAI53035 BN000155 CAD89266 W68831 NM_001013579 NP_001013597 |
Function | Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20). {ECO:0000269|PubMed:15671038}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Tissue Specificity | Predominantly expressed in skin, where it is limited to the sebaceous gland. Expressed in more mature, centrally located cells just before their rupture and sebum release. Also expressed in all tissues except spleen. Expressed at higher level in thymus, prostate and testis. {ECO:0000269|PubMed:15671038}. |
Anti-DGAT2L3 antibody - ab104855 from Abcam
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Anti-DGAT2L3 antibody - ab104856 from Abcam
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Anti-DGAT2L3 antibody - ab168563 from Abcam
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Anti-AWAT1 / DGAT2L3 Antibody (aa261-310) - LS-C198664 from LifeSpan Bioscience
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Anti-AWAT1 / DGAT2L3 Antibody - LS-C307224 from LifeSpan Bioscience
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Anti-AWAT1 / DGAT2L3 Antibody (aa250-299) - LS-C200168 from LifeSpan Bioscience
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Anti-AWAT1 / DGAT2L3 Antibody (aa71-120) - LS-C110969 from LifeSpan Bioscience
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Anti-AWAT1 / DGAT2L3 Antibody (aa107-156) - LS-C110970 from LifeSpan Bioscience
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AWAT1 Antibody - NBP1-59866 from Novus Biologicals
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AWAT1 Antibody - NBP1-59865 from Novus Biologicals
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Anti-AWAT1, (N-terminal) antibody produced in rabbit - SAB2105599 from Sigma-Aldrich
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Anti-DGAT2L3 antibody produced in mouse - SAB1408929 from Sigma-Aldrich
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Anti-AWAT1, (N-terminal) antibody produced in rabbit - SAB2105598 from Sigma-Aldrich
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Anti-AWAT1, C-Terminal antibody produced in rabbit - SAB4500607 from Sigma-Aldrich
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AWAT1 antibody - N-terminal region (ARP44651_P050) - ARP44651_P050 from Aviva Systems Biology
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AWAT1 antibody - N-terminal region (ARP44652_P050) - ARP44652_P050 from Aviva Systems Biology
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AWAT1 antibody - GTX87349 from GeneTex
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Anti -AWAT1 (Acyl-CoA Wax Alcohol Acyltransferase 1, Diacylglycerol O-acyltransferase2-like Protein 3, Diacylglycerol Acyltransferase 2, Long-chain-alcoholO-fatty-acyltransferase 1, DGA2, DGAT2L3) - 125790 from USBiological Life Science
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AWAT1 Antibody (OAAF03224) - OAAF03224 from Aviva Systems Biology
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AWAT1 Antibody (OAAF06136) - OAAF06136 from Aviva Systems Biology
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AWAT1 antibody - 70R-6782 from Fitzgerald
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AWAT1 antibody - 70R-33986 from Fitzgerald
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AWAT1 antibody - 70R-6781 from Fitzgerald
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DGAT2L3 / AWAT1 antibody - H00158833-B01P from Acris Antibodies
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Anti-DGAT2L3 antibody - STJ92694 from St John's Laboratory Ltd
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