Gene Symbol | THPO |
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Entrez Gene | 7066 |
Alt Symbol | MGDF, MKCSF, ML, MPLLG, THCYT1, TPO |
Species | Human |
Gene Type | protein-coding |
Description | thrombopoietin |
Other Description | MPL ligand|c-mpl ligand|megakaryocyte colony-stimulating factor|megakaryocyte growth and development factor|megakaryocyte stimulating factor|myeloproliferative leukemia virus oncogene ligand|prepro-thrombopoietin |
Swissprots | P40225 B7ZLR8 A1L3Y0 Q15791 Q15792 Q15790 B9EGA8 Q13020 |
Accessions | AAA74083 AAB33390 AAC37568 BAA06807 EAW78243 EAW78244 EAW78245 P40225 AA479058 AA480029 AB014681 BAA34930 AB014682 BAA34931 AB014683 BAA34932 AB102890 BAD89419 AB102892 BAD89421 AB102894 BAD89423 AK311002 BC130322 AAI30323 BC136338 AAI36339 BC143982 AAI43983 BX108191 D32047 BAA21930 L33410 AAA59857 L36052 AAC37566 U11025 AAA50553 U42977 U59493 AAB03392 U59494 AAB03393 U59495 AAB03394 XM_011513113 XP_011511415 NM_000460 NP_000451 NM_001177597 NP_001171068 NM_001177598 NP_001171069 NM_001289997 NP_001276926 NM_001289998 NP_001276927 NM_001290003 NP_001276932 NM_001290022 NP_001276951 NM_001290026 NP_001276955 NM_001290027 NP_001276956 NM_001290028 NP_001276957 NM_199228 NM_199356 |
Function | Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. |
Subcellular Location | Secreted. |
Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage |
THPO-Over-expression-Lysate - LY10057a from Abgent, a WuXi AppTec company
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THPO 293T Cell Transient Overexpression Lysate(Denatured) - H00007066-T01 from Acris Antibodies
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THPO overexpression lysate - LY424704 from Acris Antibodies
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THPO overexpression lysate - LY432926 from Acris Antibodies
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Thrombopoietin/Tpo Overexpression Lysate (Denatured) - H00007066-T01 from Novus Biologicals
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Human Thrombopoietin / THPO HEK293 Cell Lysate (WB positive control) - 10381-H08HL-300 from Sino Biological
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Cynomolgus Thrombopoietin / THPO / TPO HEK293 Cell Lysate (WB positive control) - 90004-C08HL-300 from Sino Biological
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Human Thrombopoietin / THPO HEK293 Cell Lysate (WB positive control) - 10381-H08H1L-300 from Sino Biological
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Human Thrombopoietin / THPO / TPO CHO Cell Lysate (WB positive control) - 10381-H08CL-300 from Sino Biological
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Human Thrombopoietin / THPO / TPO HEK293 Cell Lysate (WB positive control) - 10381-H07HL-300 from Sino Biological
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Human Thrombopoietin / THPO HEK293 Cell Lysate (WB positive control) - 10381-H02HL-300 from Sino Biological
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Human Thrombopoietin Human Cells Transfected Lysate (positive control) (denatured) - orb173025 from Biorbyt
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Human Thrombopoietin Human Cells Transfected Lysate (positive control) (denatured) - orb232821 from Biorbyt
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Thrombopoietin/Tpo Overexpression Lysate (Native) - NBP2-10672 from Novus Biologicals
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Human Thrombopoietin Human Cells Transfected Lysate (positive control) (denatured) - orb232822 from Biorbyt
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Human Thrombopoietin Human Cells Transfected Lysate (positive control) (denatured) - orb232820 from Biorbyt
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Panoply™ Human THPO Knockdown Stable Cell Line - CSC-DC015920 from Creative biogene
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