RIPK2

Gene Symbol RIPK2
Entrez Gene 8767
Alt Symbol CARD3, CARDIAK, CCK, GIG30, RICK, RIP2
Species Human
Gene Type protein-coding
Description receptor-interacting serine-threonine kinase 2
Other Description CARD-carrying kinase|CARD-containing IL-1 beta ICE-kinase|CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase|RIP-2|growth-inhibiting gene 30|receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase|receptor-interacting protein 2|receptor-interacting serine/threonine-protein kinase 2|tyrosine-protein kinase RIPK2
Swissprots O43353 B7Z748 Q6UWF0
Accessions AAC24561 EAW91655 EAW91656 O43353 AF027706 AAC34970 AF064824 AAC25668 AF078530 AAC27722 AI824070 AK075213 BAG52085 AK301448 BAH13484 AY358813 AAQ89172 AY358814 AAQ89173 AY524045 AAS94254 AY562996 AAS75586 BC004553 AAH04553 DA040898 XM_005251092 XP_005251149 XM_011517357 XP_011515659 NM_003821 NP_003812
Function Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-ce
Subcellular Location Cytoplasm {ECO:0000305}.
Tissue Specificity Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
Top Pathways Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Tuberculosis

RIPK2-Over-expression-Lysate - LY10610a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag RIPK2 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the RIPK2 gene (Lane 2, Cat. #LY10610a).

RIPK2 293T Cell Transient Overexpression Lysate(Denatured) - H00008767-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

RIPK2 overexpression lysate - LY418408 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

RIPK2 293 Cell Lysate - 408586 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

RIPK2 Overexpression Lysate (Native) - NBL1-15378 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: RIPK2 Overexpression Lysate (Adult Normal) [NBL1-15378] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RIPK2.

RIPK2 Over-expression Lysate Product - GWB-3BCB18 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

RIPK2 Overexpression Lysate (Denatured) - H00008767-T01 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

RIPK2 Overexpression Lysate (Denatured) - H00008767-T02 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

RIPK2-knockout Cell lysate - LC810273 from Acris Antibodies

Category Cell Lysate
Prices $495.00
Sizes 100 µg

Panoply™ Human RIPK2 Knockdown Stable Cell Line - CSC-DC013323 from Creative biogene

Category Cell Line
Species Human

Human RIPK2 Knockout Cell Line-HeLa - CSC-RT0717 from Creative biogene

Category Cell Line
Species Human

RIPK2 KO Cell Lysate-HeLa - CLKO-0222 from Creative biogene

Category Cell Lysate
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