RIPK2

Gene Symbol RIPK2
Entrez Gene 8767
Alt Symbol CARD3, CARDIAK, CCK, GIG30, RICK, RIP2
Species Human
Gene Type protein-coding
Description receptor-interacting serine-threonine kinase 2
Other Description CARD-carrying kinase|CARD-containing IL-1 beta ICE-kinase|CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase|RIP-2|growth-inhibiting gene 30|receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase|receptor-interacting protein 2|receptor-interacting serine/threonine-protein kinase 2|tyrosine-protein kinase RIPK2
Swissprots O43353 B7Z748 Q6UWF0
Accessions AAC24561 EAW91655 EAW91656 O43353 AF027706 AAC34970 AF064824 AAC25668 AF078530 AAC27722 AI824070 AK075213 BAG52085 AK301448 BAH13484 AY358813 AAQ89172 AY358814 AAQ89173 AY524045 AAS94254 AY562996 AAS75586 BC004553 AAH04553 DA040898 XM_005251092 XP_005251149 XM_011517357 XP_011515659 NM_003821 NP_003812
Function Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-ce
Subcellular Location Cytoplasm {ECO:0000305}.
Tissue Specificity Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
Top Pathways Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Tuberculosis

RICK CRISPR/Cas9 KO Plasmid (h) - sc-400731 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RICK HDR Plasmid (h) - sc-400731-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RICK Double Nickase Plasmid (h) - sc-400731-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RICK Double Nickase Plasmid (h2) - sc-400731-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RICK CRISPR Activation Plasmid (h) - sc-400731-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RICK CRISPR Activation Plasmid (h2) - sc-400731-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RICK Lentiviral Activation Particles (h) - sc-400731-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RICK Lentiviral Activation Particles (h2) - sc-400731-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RICK siRNA (h) - sc-37389 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RICK shRNA Plasmid (h) - sc-37389-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RICK shRNA (h) Lentiviral Particles - sc-37389-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU033261 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1966 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1967 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1965 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2179 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2179 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

RIPK2 siRNA (Human) - CRH5775 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RIPK2 RNAi - H00008767-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

RIPK2 - MBS8233718 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RIPK2 (NM_003821.5) - SHH396008 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human RIPK2(NM_003821.5) - SHR182882 from Creative biogene

Category siRNA
Species Reactivities Human

Human RIPK2 siRNA - orb266277 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RIPK2 shRNA Plasmid (Human) - CHH5775 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RIPK2 miRNA 3'UTR clone - MiUTR1H-08834 from Creative biogene

Species Reactivities Human
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