RIPK2

Gene Symbol	RIPK2
Entrez Gene	8767
Alt Symbol	CARD3, CARDIAK, CCK, GIG30, RICK, RIP2
Species	Human
Gene Type	protein-coding
Description	receptor-interacting serine-threonine kinase 2
Other Description	CARD-carrying kinase|CARD-containing IL-1 beta ICE-kinase|CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase|RIP-2|growth-inhibiting gene 30|receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase|receptor-interacting protein 2|receptor-interacting serine/threonine-protein kinase 2|tyrosine-protein kinase RIPK2
Swissprots	O43353 B7Z748 Q6UWF0
Accessions	AAC24561 EAW91655 EAW91656 O43353 AF027706 AAC34970 AF064824 AAC25668 AF078530 AAC27722 AI824070 AK075213 BAG52085 AK301448 BAH13484 AY358813 AAQ89172 AY358814 AAQ89173 AY524045 AAS94254 AY562996 AAS75586 BC004553 AAH04553 DA040898 XM_005251092 XP_005251149 XM_011517357 XP_011515659 NM_003821 NP_003812
Function	Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-ce
Subcellular Location	Cytoplasm {ECO:0000305}.
Tissue Specificity	Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
Top Pathways	Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human RIP2 protein - ab60879 from Abcam Category Protein Prices $278.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human RIP2 full length protein - ab131787 from Abcam Category Protein Source Wheat germ Species Human

Human RIP2 peptide - ab8462 from Abcam Category Peptide Species Human

Human RIP2 peptide - ab8463 from Abcam Category Peptide Species Human

Human RIP2 protein fragment - ab152912 from Abcam Category Protein Source Wheat germ Species Human

RICK / RIP2 Antibody Blocking Peptide - LS-E10614 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RICK / RIP2 Antibody Blocking Peptide - LS-E9288 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RICK / RIP2 Antibody Blocking Peptide - LS-E29880 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

RICK / RIP2 Antibody Blocking Peptide - LS-E29909 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human RIPK2 Protein - H00008767-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human RIPK2 Protein - H00008767-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Cholecystokinin Protein - H00000885-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RIPK2 Recombinant Protein - P4230 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

RIPK2 Recombinant Protein - P4769 from Novus Biologicals Category Protein Prices $1,599.00 Sizes 100 µg Species Human

RIPK2 Blocking Peptide - NBP1-76960PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

RIPK2 Blocking Peptide - NBP1-76873PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant RIPK2 Protein - NBP1-99499 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

RIPK2 Peptide - P2841 from Novus Biologicals Category Peptide Species Human

RIPK2-Antibody-N-term-Blocking-peptide - BP13758a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RIPK2-Antibody-C-term-Blocking-Peptide - BP7818b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RIP2 (Active) recombinant protein - GTX65297 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

RIP2 peptide - GTX28462 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

RIP2 peptide - GTX28463 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

Human RIPK2 protein - orb246430 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

CCK Blocking Peptide - 33R-4121 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

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