RIPK2

Gene Symbol	RIPK2
Entrez Gene	8767
Alt Symbol	CARD3, CARDIAK, CCK, GIG30, RICK, RIP2
Species	Human
Gene Type	protein-coding
Description	receptor-interacting serine-threonine kinase 2
Other Description	CARD-carrying kinase|CARD-containing IL-1 beta ICE-kinase|CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase|RIP-2|growth-inhibiting gene 30|receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase|receptor-interacting protein 2|receptor-interacting serine/threonine-protein kinase 2|tyrosine-protein kinase RIPK2
Swissprots	O43353 B7Z748 Q6UWF0
Accessions	AAC24561 EAW91655 EAW91656 O43353 AF027706 AAC34970 AF064824 AAC25668 AF078530 AAC27722 AI824070 AK075213 BAG52085 AK301448 BAH13484 AY358813 AAQ89172 AY358814 AAQ89173 AY524045 AAS94254 AY562996 AAS75586 BC004553 AAH04553 DA040898 XM_005251092 XP_005251149 XM_011517357 XP_011515659 NM_003821 NP_003812
Function	Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-ce
Subcellular Location	Cytoplasm {ECO:0000305}.
Tissue Specificity	Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
Top Pathways	Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Phospho-RIP2 (Ser176) (E1I9J) Rabbit mAb - 14397 from Cell Signaling Technology Prices $287.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone E1I9J

Phospho-RIP2 (Ser176) Antibody - 4364 from Cell Signaling Technology Prices $279.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

RIP2 (D10B11) Rabbit mAb - 4142 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D10B11

RIP2 Antibody - 4982 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

RICK (N-19) - sc-8610 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

RICK (A-10) - sc-166765 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

RICK (H-300) - sc-22763 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

RICK (C-19) - sc-8611 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

RICK (25) - sc-136059 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

Anti-RIP2 antibody - ab8428 from Abcam Prices $378.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RIP2 antibody - ab8427 from Abcam Prices $372.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RIP2 antibody - ab57954 from Abcam Prices $378.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-RIP2 antibody - ab155529 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RIP2 antibody - ab85264 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RIP2 antibody - ab57952 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-RIP2 antibody [AF28D3] - ab75257 from Abcam Prices $378.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone AF28D3

Anti-RIP2 antibody [EPR4224(2)] - ab108971 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4224(2)

Anti-RIP2 antibody [Nick-1] - ab17328 from Abcam Prices $376.00 Sizes 50 µg Host Rat Clonality Monoclonal Clone Nick-1

Anti-RICK / RIP2 Antibody (aa146-195) - LS-C199543 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RICK / RIP2 Antibody (clone 6F7) - LS-C133569 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 6F7

Anti-RICK / RIP2 Antibody (clone 3D9) - LS-C133570 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3D9

Anti-RICK / RIP2 Antibody (clone 7F5) IHC-plus™ - LS-B10054 from LifeSpan Bioscience Prices $450.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 7F5

Anti-RICK / RIP2 Antibody (aa39-68) - LS-C162614 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-RICK / RIP2 Antibody (aa458-488) - LS-C97216 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-RICK / RIP2 Antibody - LS-C332122 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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