| Gene Symbol |
STYK1
|
| Entrez Gene |
55359
|
| Alt Symbol |
NOK, SuRTK106
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serine/threonine/tyrosine kinase 1
|
| Other Description |
novel oncogene with kinase domain|protein PK-unique|tyrosine-protein kinase STYK1
|
| Swissprots |
Q9NSH1 B2R9T2 Q9BXY2 Q6J9G0 Q52LR3
|
| Accessions |
EAW96200 Q6J9G0 AF251059 AAK34949 AK313906 BAG36629 AL353940 CAB89250 AM393808 CAL38683 AY563054 AAT01226 BC093822 AAH93822 BC093824 AAH93824 KP729000 AJM21857 XM_005253417 XP_005253474 XM_011520736 XP_011519038 XM_011520737 XP_011519039 XM_011520738 XP_011519040 XM_011520739 XP_011519041 NM_018423 NP_060893
|
| Function |
Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most normal lung tissues, widely expressed in lung cancers. {ECO:0000269|PubMed:12841579, ECO:0000269|PubMed:15150103, ECO:0000269|PubMed:17298854}.
|