STYK1

Gene Symbol STYK1
Entrez Gene 55359
Alt Symbol NOK, SuRTK106
Species Human
Gene Type protein-coding
Description serine/threonine/tyrosine kinase 1
Other Description novel oncogene with kinase domain|protein PK-unique|tyrosine-protein kinase STYK1
Swissprots Q9NSH1 B2R9T2 Q9BXY2 Q6J9G0 Q52LR3
Accessions EAW96200 Q6J9G0 AF251059 AAK34949 AK313906 BAG36629 AL353940 CAB89250 AM393808 CAL38683 AY563054 AAT01226 BC093822 AAH93822 BC093824 AAH93824 KP729000 AJM21857 XM_005253417 XP_005253474 XM_011520736 XP_011519038 XM_011520737 XP_011519039 XM_011520738 XP_011519040 XM_011520739 XP_011519041 NM_018423 NP_060893
Function Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). {ECO:0000250}.
Subcellular Location Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue Specificity Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most normal lung tissues, widely expressed in lung cancers. {ECO:0000269|PubMed:12841579, ECO:0000269|PubMed:15150103, ECO:0000269|PubMed:17298854}.

NOK (2H2F10) - sc-81701 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NOK (2H2F10): sc-81701. Western blot analysis of truncated human recombinant NOK protein (A) and NOK expression in NOK transfected CHO-K1 cells (B).

NOK (E-15) - sc-109342 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NOK (E-15): sc-109342. Western blot analysis of NOK expression in U-87 MG whole cell lysate.

NOK (H-222) - sc-366195 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

NOK (P-14) - sc-109343 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NOK (Q-21) - sc-133836 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
NOK (Q-21): sc-133836. Western blot analysis of NOK expression in Hep G2 whole cell lysate.

Anti-Styk1 antibody - ab97451 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Styk1 antibody (ab97451) at 1/1000 dilutionLane 1 : A431 whole cell lysateLane 2 : MOLT4 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Styk1 antibody - ab92912 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Styk1 antibody (ab92912) at 1/500 dilutionLane 1 : transfected 293T cell lysateLane 2 : non transfected 293T cell lysateLysates/proteins at 25 µg per lane.

Anti-Styk1 antibody - ab55041 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Styk1 antibody - ab55040 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab55040 Styk1 antibody at 1ug/ml.

Anti-Styk1 antibody [2H2F10] - ab63570 from Abcam

Host Mouse
Clonality Monoclonal
Clone 2H2F10
Overlay histogram showing HeLa cells stained with ab63570 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab63570, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-STYK1 / NOK / SuRTK106 Antibody (aa295-344) - LS-C81061 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 0.25 ug/ml. Gel concentration: 12%.

Anti-STYK1 Antibody (N-Terminus, AP) - LS-C246031 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STYK1 Antibody (N-Terminus, APC) - LS-C246032 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STYK1 Antibody (N-Terminus, Biotin) - LS-C246033 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STYK1 Antibody (N-Terminus) - LS-C99403 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
The anti- STYK1 antibody is used in Western blot to detect STYK1 in 293 , CEM , and mouse kidney cell line/tissue lysates.

Anti-STYK1 Antibody (N-Terminus, FITC) - LS-C246034 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STYK1 Antibody (N-Terminus, PE) - LS-C246037 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STYK1 Antibody (N-Terminus, Azide-free, HRP) - LS-C247902 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STYK1 Antibody (N-Terminus) - LS-C330678 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STYK1 Antibody (aa145-194) - LS-C201532 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Mouse Small Intestine. Styk1 antibody dilution 1.0 ug/ml.

Anti-STYK1 Antibody (aa214-422) - LS-C185738 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded Breast CA using STYK1 antibody at 1:100 dilution.

Anti-STYK1 Antibody (clone 2H2F10) IHC-plus™ - LS-B3469 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 2H2F10
Anti-STYK1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3469 dilution 1:200.

STYK1 Antibody (484713) - MAB6668 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 484713
Western blot shows lysates of SW480 human colorectal adenocarcinoma cell line, DLD clone 2C2 human colon adenocarcinoma cell line, and T47D human breast cancer cell line. PVDF Membrane was probed with 2 µg/mL of Mouse Anti-Human STYK1 Monoclonal Antibody (Catalog # MAB6668) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for STYK1 at approximately 48 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

STYK1 Antibody (2H2F10) - NBP1-47511 from Novus Biologicals

Prices $369.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2H2F10
Western Blot: STYK1 Antibody (2H2F10) [NBP1-47511] - Western blot analysis using anti-STYK1 mAb against truncated STYK1 recombinant protein(1) and STYK1(aa47-422)-hIgGFc transfected CHO-K1 cell lysate(2).

STYK1 Antibody - NBP1-59491 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Styk1 Antibody [NBP1-59491] - HepG2 cell lysate, concentration 0.2-1 ug/ml.
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