Gene Symbol | STYK1 |
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Entrez Gene | 55359 |
Alt Symbol | NOK, SuRTK106 |
Species | Human |
Gene Type | protein-coding |
Description | serine/threonine/tyrosine kinase 1 |
Other Description | novel oncogene with kinase domain|protein PK-unique|tyrosine-protein kinase STYK1 |
Swissprots | Q9NSH1 B2R9T2 Q9BXY2 Q6J9G0 Q52LR3 |
Accessions | EAW96200 Q6J9G0 AF251059 AAK34949 AK313906 BAG36629 AL353940 CAB89250 AM393808 CAL38683 AY563054 AAT01226 BC093822 AAH93822 BC093824 AAH93824 KP729000 AJM21857 XM_005253417 XP_005253474 XM_011520736 XP_011519038 XM_011520737 XP_011519039 XM_011520738 XP_011519040 XM_011520739 XP_011519041 NM_018423 NP_060893 |
Function | Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most normal lung tissues, widely expressed in lung cancers. {ECO:0000269|PubMed:12841579, ECO:0000269|PubMed:15150103, ECO:0000269|PubMed:17298854}. |
Human Styk1 full length protein - ab132571 from Abcam
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Human Styk1 protein fragment - ab125536 from Abcam
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Human Styk1 protein fragment - ab163082 from Abcam
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STYK1 Antibody Blocking Peptide - LS-E9228 from LifeSpan Bioscience
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STYK1 Antibody Blocking Peptide - LS-E17199 from LifeSpan Bioscience
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Recombinant Human STYK1 Protein - H00055359-P01 from Novus Biologicals
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Recombinant Human STYK1 Protein - H00055359-Q01 from Novus Biologicals
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STYK1 Peptide - P2775 from Novus Biologicals
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STYK1-Antibody-N-term-Blocking-Peptide - BP7729a from Abgent, a WuXi AppTec company
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STYK1 Blocking Peptide - 33R-7060 from Fitzgerald
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STYK1 / NOK - H00055359-P01-10 from Acris Antibodies
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STYK1 / NOK - H00055359-P01-25 from Acris Antibodies
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STYK1 / NOK - H00055359-Q01-10 from Acris Antibodies
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STYK1 / NOK - H00055359-Q01-25 from Acris Antibodies
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STYK1 fusion protein - ag12594 from Proteintech Group
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Recombinant Human STYK1, GST-tagged - STYK1-7023H from Creative Biomart
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Recombinant Human STYK1, GST-tagged - STYK1-3038H from Creative Biomart
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STYK1 (NOK) protein-GST fusion - 009-001-T65 from Rockland Immunochemicals Inc
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STYK1 (NOK) protein-GST fusion - 009-001-T65S from Rockland Immunochemicals Inc
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STYK1 / NOK - TP310846 from Acris Antibodies
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STYK1 Recombinant Protein Antigen - NBP2-13398PEP from Novus Biologicals
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STYK1 Peptide, Human - M34GP15374H from Creative Peptides
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STYK1(NOK), Recombinant Protein - MBS515289 from MyBioSource
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