| Gene Symbol |
RFFL
|
| Entrez Gene |
117584
|
| Alt Symbol |
CARP-2, CARP2, FRING, RIFIFYLIN, RNF189, RNF34L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase rififylin|FYVE-RING finger protein SAKURA|RING finger and FYVE-like domain-containing protein 1|RING finger protein 189|caspase regulator CARP2|caspases-8 and -10-associated RING finger protein 2|ring finger and FYVE-like domain containing 1
|
| Swissprots |
E1P633 Q8NHW0 Q8TBY7 Q96BE6 Q8WZ73
|
| Accessions |
EAW80172 EAW80173 EAW80176 EAW80177 EAW80178 Q8WZ73 AF434816 AAL30771 AK093112 BAC04059 AK308689 AY098935 AAM29181 BC015681 AAH15681 BC028424 AAH28424 BG771625 CK001659 CR933651 CAI45952 DB459719 HQ447207 ADQ31694 NM_057178 NM_001017368 NP_001017368 NR_037713
|
| Function |
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:183821
|
| Subcellular Location |
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Recycling endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The FYVE-type zinc finger may mediate phosphatidylinositol phosphate- binding and control subcellular localization.
|
| Tissue Specificity |
Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:15069192}.
|
