RFFL

Gene Symbol	RFFL
Entrez Gene	117584
Alt Symbol	CARP-2, CARP2, FRING, RIFIFYLIN, RNF189, RNF34L
Species	Human
Gene Type	protein-coding
Description	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase rififylin|FYVE-RING finger protein SAKURA|RING finger and FYVE-like domain-containing protein 1|RING finger protein 189|caspase regulator CARP2|caspases-8 and -10-associated RING finger protein 2|ring finger and FYVE-like domain containing 1
Swissprots	E1P633 Q8NHW0 Q8TBY7 Q96BE6 Q8WZ73
Accessions	EAW80172 EAW80173 EAW80176 EAW80177 EAW80178 Q8WZ73 AF434816 AAL30771 AK093112 BAC04059 AK308689 AY098935 AAM29181 BC015681 AAH15681 BC028424 AAH28424 BG771625 CK001659 CR933651 CAI45952 DB459719 HQ447207 ADQ31694 NM_057178 NM_001017368 NP_001017368 NR_037713
Function	E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:183821
Subcellular Location	Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Recycling endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The FYVE-type zinc finger may mediate phosphatidylinositol phosphate- binding and control subcellular localization.
Tissue Specificity	Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:15069192}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Rffl full length protein - ab125749 from Abcam Category Protein Source E. coli Species Human

RFFL Antibody Blocking Peptide - LS-E15819 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RFFL Antibody Blocking Peptide - LS-E15818 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RFFL Antibody Blocking Peptide - LS-E6642 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Rffl Protein - H00117584-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Rffl Protein - H00117584-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RFFL-AntibodyC-term-Blocking-peptide - BP19448b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RFFL Blocking Peptide - 33R-4301 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RFFL / RNF189 - H00117584-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RFFL / RNF189 - H00117584-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RFFL / RNF189 - H00117584-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RFFL / RNF189 - H00117584-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RFFL fusion protein - Ag3380 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human RFFL, GST-tagged - RFFL-2259H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human RFFL, His-tagged - RFFL-107H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human E3 ubiquitin-protein ligase rififylin(RFFL) - CSB-YP848846HU CSB-EP848846HU CSB-BP848846HU CSB-MP848846HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Rffl Recombinant Protein Antigen - NBP1-83427PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Rffl Recombinant Protein Antigen - NBP1-83426PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RFFL Peptide, Human - M34GP13191H from Creative Peptides Category Peptide Source Synthetic. Species Human

E3 ubiquitin-protein ligase rififylin (RFFL), Recombinant Protein - MBS1466992 from MyBioSource Category Protein Prices $1,130.00, $1,130.00, $1,360.00, $1,360.00, $1,795.00, $1,795.00, $2,260.00, $2,260.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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