RFFL

Gene Symbol	RFFL
Entrez Gene	117584
Alt Symbol	CARP-2, CARP2, FRING, RIFIFYLIN, RNF189, RNF34L
Species	Human
Gene Type	protein-coding
Description	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase rififylin|FYVE-RING finger protein SAKURA|RING finger and FYVE-like domain-containing protein 1|RING finger protein 189|caspase regulator CARP2|caspases-8 and -10-associated RING finger protein 2|ring finger and FYVE-like domain containing 1
Swissprots	E1P633 Q8NHW0 Q8TBY7 Q96BE6 Q8WZ73
Accessions	EAW80172 EAW80173 EAW80176 EAW80177 EAW80178 Q8WZ73 AF434816 AAL30771 AK093112 BAC04059 AK308689 AY098935 AAM29181 BC015681 AAH15681 BC028424 AAH28424 BG771625 CK001659 CR933651 CAI45952 DB459719 HQ447207 ADQ31694 NM_057178 NM_001017368 NP_001017368 NR_037713
Function	E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:183821
Subcellular Location	Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Recycling endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The FYVE-type zinc finger may mediate phosphatidylinositol phosphate- binding and control subcellular localization.
Tissue Specificity	Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:15069192}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Anti-Rffl antibody - ab151488 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Rffl antibody - ab57316 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-RFFL Antibody (aa265-294, AP) - LS-C223866 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RFFL Antibody (aa265-294, APC) - LS-C223867 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RFFL Antibody (aa265-294, Biotin) - LS-C223868 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RFFL Antibody (aa265-294, FITC) - LS-C223869 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RFFL Antibody (aa265-294, Azide-free, HRP) - LS-C223870 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RFFL Antibody (aa265-294, PE) - LS-C223871 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RFFL Antibody (aa265-294) - LS-C324626 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RFFL Antibody (N-Terminus) - LS-C146328 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RFFL Antibody (aa287-336) - LS-C116223 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RFFL Antibody (aa265-294) - LS-C155984 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-RFFL Antibody - LS-C334750 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RFFL Antibody (aa1-363) IHC-plus™ - LS-B416 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Rffl Antibody - NBP1-55375 from Novus Biologicals Prices $369.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Rffl Antibody - NBP1-83426 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rffl Antibody - NBP2-20137 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rffl Antibody (3A4) - H00117584-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3A4

Rffl Antibody - NBP1-83427 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rffl Antibody - H00117584-A01 from Novus Biologicals Host Mouse Clonality Polyclonal

RING finger protein 189 Antibody - bs-6872R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit

Anti-RFFL antibody produced in rabbit - SAB2105492 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RFFL antibody produced in rabbit - HPA017910 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RFFL antibody produced in rabbit - HPA019492 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RFFL antibody - middle region (ARP42986_P050) - ARP42986_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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