RFFL

Gene Symbol	RFFL
Entrez Gene	117584
Alt Symbol	CARP-2, CARP2, FRING, RIFIFYLIN, RNF189, RNF34L
Species	Human
Gene Type	protein-coding
Description	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase rififylin|FYVE-RING finger protein SAKURA|RING finger and FYVE-like domain-containing protein 1|RING finger protein 189|caspase regulator CARP2|caspases-8 and -10-associated RING finger protein 2|ring finger and FYVE-like domain containing 1
Swissprots	E1P633 Q8NHW0 Q8TBY7 Q96BE6 Q8WZ73
Accessions	EAW80172 EAW80173 EAW80176 EAW80177 EAW80178 Q8WZ73 AF434816 AAL30771 AK093112 BAC04059 AK308689 AY098935 AAM29181 BC015681 AAH15681 BC028424 AAH28424 BG771625 CK001659 CR933651 CAI45952 DB459719 HQ447207 ADQ31694 NM_057178 NM_001017368 NP_001017368 NR_037713
Function	E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:183821
Subcellular Location	Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Recycling endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The FYVE-type zinc finger may mediate phosphatidylinositol phosphate- binding and control subcellular localization.
Tissue Specificity	Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:15069192}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RFFL CRISPR/Cas9 KO Plasmid (h) - sc-414118 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RFFL HDR Plasmid (h) - sc-414118-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RFFL Double Nickase Plasmid (h) - sc-414118-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RFFL Double Nickase Plasmid (h2) - sc-414118-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RFFL CRISPR Activation Plasmid (h) - sc-414118-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RFFL CRISPR Activation Plasmid (h2) - sc-414118-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RFFL Lentiviral Activation Particles (h) - sc-414118-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RFFL Lentiviral Activation Particles (h2) - sc-414118-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RFFL siRNA (h) - sc-93845 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RFFL shRNA Plasmid (h) - sc-93845-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RFFL shRNA (h) Lentiviral Particles - sc-93845-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rffl RNAi - H00117584-R01V from Novus Biologicals Category siRNA Prices $629.00 Sizes 20 nmol Species Reactivities Human

Rffl RNAi - H00117584-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Rffl RNAi - H00117584-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU095531 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18170 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18170 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11820 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr11820

RFFL siRNA (Human) - CRJ4575 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RFFL - MBS8228702 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human RFFL(NM_001017368.1) - SHR177312 from Creative biogene Category siRNA Species Reactivities Human

RFFL shRNA Plasmid (Human) - CHJ4575 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

RFFL miRNA 3'UTR clone - MiUTR1H-08754 from Creative biogene Species Reactivities Human

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