PXDN

Gene Symbol	PXDN
Entrez Gene	7837
Alt Symbol	COPOA, D2S448, D2S448E, MG50, PRG2, PXN, VPO
Species	Human
Gene Type	protein-coding
Description	peroxidasin
Other Description	melanoma-associated antigen MG50\|p53-responsive gene 2 protein\|peroxidasin homolog\|vascular peroxidase 1
Swissprots	A8QM65 Q92626 D6W4Y0 Q4KMG2
Accessions	EAX01084 EAX01085 Q92626 AF200348 AAF06354 AK098167 BC009496 AAH09496 BC030834 BC041027 BC070119 BC098579 AAH98579 BC140295 AAI40296 BG706125 BX348948 CN359024 CN359026 D86983 BAA13219 DA551404 DA866300 EF090903 ABO25865 XM_005264707 XP_005264764 XM_011510395 XP_011508697 XM_011510396 XP_011508698 XM_011510397 XP_011508699 NM_012293 NP_036425
Function	Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation. {ECO:0000269\|PubMed:18929642, ECO:0000269\|PubMed:19590037}.
Subcellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000269\|PubMed:19590037, ECO:0000269\|Ref.8}. Note=Enriched in the peritubular space of fibrotic kidneys.
Tissue Specificity	Expressed at higher levels in heart, lung, ovary, spleen, intestine and placenta, and at lower levels in liver, colon, pancreas, kidney, thymus, skeletal muscle and prostate. Expressed in tumors such as melanoma, breast cancer, ovarian cancer and glioblastoma. A shorter form probably lacking the signal sequence is found in testis and in EB1 cells undergoing p53/TP53-dependent apoptosis. {ECO:0000269\|PubMed:10441517, ECO:0000269\|PubMed:11103812, ECO:0000269\|PubMed:18929642, ECO:0000269\|PubMed:19590037}.

MG50 (P-12) - sc-168598 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-PXDN antibody - ab76447 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-PXDN antibody (ab76447) at 5 µg/ml + immunogen at 0.2 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

Anti-PXDN / MG50 Antibody (aa76-260, Biotin) - LS-C297250 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PXDN / MG50 Antibody (aa1285-1475, Biotin) - LS-C297391 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PXDN / MG50 Antibody (aa76-260, FITC) - LS-C304113 from LifeSpan Bioscience

Prices	$485.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PXDN / MG50 Antibody (aa1285-1475, FITC) - LS-C304993 from LifeSpan Bioscience

Prices	$485.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PXDN / MG50 Antibody (clone 2C11) - LS-C198500 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2C11

Detection limit for recombinant GST tagged PXDN is 0.03 ng/ml as a capture antibody.

Anti-PXDN / MG50 Antibody (aa111-160) - LS-C201416 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of Human COLO205. PXDN antibody dilution 1.0 ug/ml.

Anti-PXDN / MG50 Antibody (aa1285-1475) - LS-C295808 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of recombinant PXDN / MG50.

Anti-PXDN / MG50 Antibody (aa76-260) - LS-C295809 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

PXDN Antibody - NBP1-84316 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry: PXDN Antibody [NBP1-84316] - Immunohistochemical staining of human stomach shows cytoplasmic positivity in glandular cells.

PXDN Antibody - H00007837-A01 from Novus Biologicals

Prices	$269.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Western Blot: PXDN Antibody [H00007837-A01] - PXDN polyclonal antibody (A01), Lot # 061130JCS1 Western Blot analysis of PXDN expression in SJCRH30 ( Cat # L027V1 ).

PXDN Antibody (2C11) - H00007837-M03 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2C11

Monoclonal Anti-PXDN antibody produced in mouse - SAB1402973 from Sigma-Aldrich

Prices	$347.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2C11

<B>Immunoblotting</B><BR/>Monoclonal Anti-PXDN: <B>Cat. No. SAB1402973</B>: Antibody concentration: 1 μg/mL. Specific band of ~38.2 kDa using immunogen protein lysate.

Anti-PXDN antibody produced in rabbit - HPA012375 from Sigma-Aldrich

Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-PXDN: <B>Cat. No. HPA012375</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human stomach shows cytoplasmic positivity in glandular cells.

PXDN Antibody - N-terminal region (ARP42360_P050) - ARP42360_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

PRG2 antibody [BMK13] - GTX40448 from GeneTex

Prices	$319.00
Sizes	100 μg
Host	Mouse
Clonality	Monoclonal
Clone	BMK13

Paxillin (phospho Tyr118) antibody - GTX50155 from GeneTex

Prices	$319.00
Sizes	100 μl
Host	Rabbit
Clonality	Polyclonal

Anti-Paxillin (phospho Tyr118) antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX50155

Paxillin (phospho Tyr181) antibody [EP41(2)Y] - GTX61716 from GeneTex

Host	Rabbit
Clonality	Monoclonal
Clone	EP41(2)Y

Anti-Paxillin (phospho Tyr181) antibody [EP41(2)Y] used in Western blot. GTX61716

Paxillin (phospho Tyr31) antibody - GTX50243 from GeneTex

Prices	$319.00
Sizes	100 μl
Host	Rabbit
Clonality	Polyclonal

Anti-Paxillin (phospho Tyr31) antibody used in Western blot. GTX50243

Paxillin (phospho Tyr31) antibody [E228] - GTX61081 from GeneTex

Prices	$329.00
Sizes	100 μl
Host	Rabbit
Clonality	Monoclonal
Clone	E228

Anti-Paxillin (phospho Tyr31) antibody [E228] used in ICC/IF. GTX61081

Paxillin (phospho Tyr88) antibody - GTX50350 from GeneTex

Prices	$319.00
Sizes	100 μl
Host	Rabbit
Clonality	Polyclonal

Anti-Paxillin (phospho Tyr88) antibody used in ICC/IF. GTX50350

Paxillin antibody - GTX50457 from GeneTex

Prices	$319.00
Sizes	100 μl
Host	Rabbit
Clonality	Polyclonal

Anti-Paxillin antibody used in Western blot. GTX50457

Paxillin antibody - GTX50528 from GeneTex

Prices	$319.00
Sizes	100 μl
Host	Rabbit
Clonality	Polyclonal

Anti-Paxillin antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX50528

Paxillin antibody - GTX50662 from GeneTex

Prices	$319.00
Sizes	100 μl
Host	Rabbit
Clonality	Polyclonal

Anti-Paxillin antibody used in ICC/IF. GTX50662

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