| Gene Symbol |
PXDN
|
| Entrez Gene |
7837
|
| Alt Symbol |
COPOA, D2S448, D2S448E, MG50, PRG2, PXN, VPO
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
peroxidasin
|
| Other Description |
melanoma-associated antigen MG50|p53-responsive gene 2 protein|peroxidasin homolog|vascular peroxidase 1
|
| Swissprots |
A8QM65 Q92626 D6W4Y0 Q4KMG2
|
| Accessions |
EAX01084 EAX01085 Q92626 AF200348 AAF06354 AK098167 BC009496 AAH09496 BC030834 BC041027 BC070119 BC098579 AAH98579 BC140295 AAI40296 BG706125 BX348948 CN359024 CN359026 D86983 BAA13219 DA551404 DA866300 EF090903 ABO25865 XM_005264707 XP_005264764 XM_011510395 XP_011508697 XM_011510396 XP_011508698 XM_011510397 XP_011508699 NM_012293 NP_036425
|
| Function |
Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation. {ECO:0000269|PubMed:18929642, ECO:0000269|PubMed:19590037}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:19590037, ECO:0000269|Ref.8}. Note=Enriched in the peritubular space of fibrotic kidneys.
|
| Tissue Specificity |
Expressed at higher levels in heart, lung, ovary, spleen, intestine and placenta, and at lower levels in liver, colon, pancreas, kidney, thymus, skeletal muscle and prostate. Expressed in tumors such as melanoma, breast cancer, ovarian cancer and glioblastoma. A shorter form probably lacking the signal sequence is found in testis and in EB1 cells undergoing p53/TP53-dependent apoptosis. {ECO:0000269|PubMed:10441517, ECO:0000269|PubMed:11103812, ECO:0000269|PubMed:18929642, ECO:0000269|PubMed:19590037}.
|