MKNK2

Gene Symbol MKNK2
Entrez Gene 2872
Alt Symbol GPRK7, MNK2
Species Human
Gene Type protein-coding
Description MAP kinase interacting serine/threonine kinase 2
Other Description G protein-coupled receptor kinase 7|MAP kinase signal-integrating kinase 2|MAP kinase-interacting serine/threonine-protein kinase 2|MAPK signal-integrating kinase 2
Swissprots Q9HBH8 Q9HBH9 Q6GPI3 Q9UHR0 Q9Y2N6
Accessions AAD21217 CAV30711 CAV30712 CBX54006 CBX54007 EAW69422 EAW69423 Q9HBH9 AB209074 BAD92311 AF125532 AAF17226 AF237775 AAG26336 AF237776 AAG26337 AK001730 BAA91866 AK023442 AK024347 AK092536 BAG52569 AK097012 AK293742 BAG57165 AK303393 BAG64449 AL137565 CAB70816 AL137615 AL513974 BC018345 AAH18345 BC021235 BC073140 AAH73140 BM977403 BU192307 DA950743 EU832311 ACE87568 EU832396 ACE86881 NM_017572 NP_060042 NM_199054 NP_951009
Function Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20
Subcellular Location Isoform 2: Nucleus, PML body.
Tissue Specificity Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1. {ECO:0000269|PubMed:11013076}.
Top Pathways Insulin signaling pathway, MAPK signaling pathway

Mnk2 (B-6) - sc-271559 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mnk2 (B-6): sc-271559. Western blot analysis of Mnk2 expression in non-transfected 293T: sc-117752 (A), human Mnk2 transfected 293T: sc-111551 (B) and HeLa (C) whole cell lysates.

Mnk2 (H-58) - sc-28781 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Mnk2 (H-58): sc-28781. Western blot analysis of Mnk2 expression in Ramos whole cell lysate.

Mnk2 (M-20) - sc-7445 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Mnk2 (M-20): sc-7445. Western blot analysis of Mnk2 expression in Ramos whole cell lysate.

Mnk2 (S-20) - sc-6964 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Mnk2 (S-20): sc-6964. Western blot analysis of Mnk2 expression in Ramos whole cell lysate.

Anti-MNK2 antibody - ab84345 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-MNK2 antibody (ab84345) at 1 µg/ml (in 5% skim milk / PBS buffer) + 721_B cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-MNK2 antibody - ab55145 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
ICC/IF image of ab55145 stained Hek293 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab55145, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96879, DyLight® 488 goat anti-mouse IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-MNK2 antibody - ab171983 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MNK2 antibody (ab171983) at 1 µg/mlLane 1 : MNK2 transfected 293T cell line lysateLane 2 : Non-ransfected 293T cell line lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG at 1/2500 dilution

Anti-MNK2 antibody - C-terminal - ab175867 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MNK2 antibody - C-terminal (ab175867) at 1/1000 dilution + 293 cell lysate at 35 µg

Anti-MKNK2 / MNK2 Antibody (clone 4F11) - LS-C197340 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4F11
Immunofluorescence of monoclonal antibody to MKNK2 on HeLa cell. [antibody concentration 25 ug/ml]

Anti-MKNK2 / MNK2 Antibody (aa36-85) IHC-plus™ - LS-B3999 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-MKNK2 / MNK2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3999 concentration 5 ug/ml.

Anti-MKNK2 / MNK2 Antibody (aa35-64, AP) - LS-C223282 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MKNK2 / MNK2 Antibody (aa35-64, APC) - LS-C223283 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MKNK2 / MNK2 Antibody (aa35-64, Biotin) - LS-C223284 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MKNK2 / MNK2 Antibody (aa35-64, FITC) - LS-C223285 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MKNK2 / MNK2 Antibody (aa402-432) - LS-C98365 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of MNK2 (MKNK2) antibody in 293 cell line lysates (35 ug/lane). MNK2 (arrow) was detected using the purified antibody.

Anti-MKNK2 / MNK2 Antibody (aa35-64, Azide-free, HRP) - LS-C223286 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MKNK2 / MNK2 Antibody (aa35-64, PE) - LS-C223288 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MKNK2 / MNK2 Antibody (C-Terminus, APC) - LS-C225804 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MKNK2 / MNK2 Antibody (C-Terminus, Biotin) - LS-C225807 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MKNK2 / MNK2 Antibody (C-Terminus, Azide-free, HRP) - LS-C225808 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MKNK2 / MNK2 Antibody (C-Terminus, PE) - LS-C225809 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MKNK2 / MNK2 Antibody (C-Terminus, AP) - LS-C225805 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MKNK2 / MNK2 Antibody (C-Terminus, FITC) - LS-C225806 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MKNK2 / MNK2 Antibody (N-Terminus, AP) - LS-C225810 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MKNK2 / MNK2 Antibody (aa70-100) - LS-C98993 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
The anti-MKNK2 antibody is used in Western blot to detect MKNK2 in mouse lung tissue lysate.
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