MKNK2

Gene Symbol	MKNK2
Entrez Gene	2872
Alt Symbol	GPRK7, MNK2
Species	Human
Gene Type	protein-coding
Description	MAP kinase interacting serine/threonine kinase 2
Other Description	G protein-coupled receptor kinase 7|MAP kinase signal-integrating kinase 2|MAP kinase-interacting serine/threonine-protein kinase 2|MAPK signal-integrating kinase 2
Swissprots	Q9HBH8 Q9HBH9 Q6GPI3 Q9UHR0 Q9Y2N6
Accessions	AAD21217 CAV30711 CAV30712 CBX54006 CBX54007 EAW69422 EAW69423 Q9HBH9 AB209074 BAD92311 AF125532 AAF17226 AF237775 AAG26336 AF237776 AAG26337 AK001730 BAA91866 AK023442 AK024347 AK092536 BAG52569 AK097012 AK293742 BAG57165 AK303393 BAG64449 AL137565 CAB70816 AL137615 AL513974 BC018345 AAH18345 BC021235 BC073140 AAH73140 BM977403 BU192307 DA950743 EU832311 ACE87568 EU832396 ACE86881 NM_017572 NP_060042 NM_199054 NP_951009
Function	Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20
Subcellular Location	Isoform 2: Nucleus, PML body.
Tissue Specificity	Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1. {ECO:0000269|PubMed:11013076}.
Top Pathways	Insulin signaling pathway, MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MNK2 full length protein - ab51441 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human MNK2 protein fragment - ab152437 from Abcam Category Protein Source Wheat germ Species Human

Human MNK2 protein fragment - ab152438 from Abcam Category Protein Source Wheat germ Species Human

MKNK2 / MNK2 Antibody Blocking Peptide - LS-E2812 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MKNK2 / MNK2 Antibody Blocking Peptide - LS-E8646 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MKNK2 / MNK2 Antibody Blocking Peptide - LS-E8724 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MKNK2 / MNK2 Antibody Blocking Peptide - LS-E19995 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MNK2 Partial Recombinant Protein - H00002872-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MNK2 Recombinant Protein - H00002872-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human MNK2 Protein - P3882 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Source Insect Species Human

MNK2 Peptide - P2160 from Novus Biologicals Category Peptide Species Human

MNK2 Peptide - P2308 from Novus Biologicals Category Peptide Species Human

MNK2-MKNK2-Antibody-N-term-Blocking-peptide - BP7058a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MNK2-MKNK2-Antibody-C-term-Blocking-peptide - BP7152a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MKNK2 Blocking Peptide - 33R-8351 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MKNK2 - H00002872-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MKNK2 - H00002872-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MKNK2 - H00002872-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MKNK2 - H00002872-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MKNK2 - P3882 from Acris Antibodies Category Protein Prices $1,230.00 Sizes 5 µg Species Human

MKNK2 - P5754 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

MKNK2 fusion protein - Ag10660 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

MKNK2 fusion protein - Ag10546 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human MKNK2, GST-tagged, Active - MKNK2-356H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human MKNK2 - MKNK2-26382TH from Creative Biomart Category Protein

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