| Gene Symbol |
MKNK2
|
| Entrez Gene |
2872
|
| Alt Symbol |
GPRK7, MNK2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MAP kinase interacting serine/threonine kinase 2
|
| Other Description |
G protein-coupled receptor kinase 7|MAP kinase signal-integrating kinase 2|MAP kinase-interacting serine/threonine-protein kinase 2|MAPK signal-integrating kinase 2
|
| Swissprots |
Q9HBH8 Q9HBH9 Q6GPI3 Q9UHR0 Q9Y2N6
|
| Accessions |
AAD21217 CAV30711 CAV30712 CBX54006 CBX54007 EAW69422 EAW69423 Q9HBH9 AB209074 BAD92311 AF125532 AAF17226 AF237775 AAG26336 AF237776 AAG26337 AK001730 BAA91866 AK023442 AK024347 AK092536 BAG52569 AK097012 AK293742 BAG57165 AK303393 BAG64449 AL137565 CAB70816 AL137615 AL513974 BC018345 AAH18345 BC021235 BC073140 AAH73140 BM977403 BU192307 DA950743 EU832311 ACE87568 EU832396 ACE86881 NM_017572 NP_060042 NM_199054 NP_951009
|
| Function |
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20
|
| Subcellular Location |
Isoform 2: Nucleus, PML body.
|
| Tissue Specificity |
Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1. {ECO:0000269|PubMed:11013076}.
|
| Top Pathways |
Insulin signaling pathway, MAPK signaling pathway
|