MKNK2

Gene Symbol	MKNK2
Entrez Gene	2872
Alt Symbol	GPRK7, MNK2
Species	Human
Gene Type	protein-coding
Description	MAP kinase interacting serine/threonine kinase 2
Other Description	G protein-coupled receptor kinase 7|MAP kinase signal-integrating kinase 2|MAP kinase-interacting serine/threonine-protein kinase 2|MAPK signal-integrating kinase 2
Swissprots	Q9HBH8 Q9HBH9 Q6GPI3 Q9UHR0 Q9Y2N6
Accessions	AAD21217 CAV30711 CAV30712 CBX54006 CBX54007 EAW69422 EAW69423 Q9HBH9 AB209074 BAD92311 AF125532 AAF17226 AF237775 AAG26336 AF237776 AAG26337 AK001730 BAA91866 AK023442 AK024347 AK092536 BAG52569 AK097012 AK293742 BAG57165 AK303393 BAG64449 AL137565 CAB70816 AL137615 AL513974 BC018345 AAH18345 BC021235 BC073140 AAH73140 BM977403 BU192307 DA950743 EU832311 ACE87568 EU832396 ACE86881 NM_017572 NP_060042 NM_199054 NP_951009
Function	Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20
Subcellular Location	Isoform 2: Nucleus, PML body.
Tissue Specificity	Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1. {ECO:0000269|PubMed:11013076}.
Top Pathways	Insulin signaling pathway, MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MKNK2 overexpression lysate - LY413712 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MKNK2 293 Cell Lysate - 403429 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

MKNK2 293 Cell Lysate - 406600 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

MNK2 Overexpression Lysate (Native) - NBL1-13125 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

MNK2 Overexpression Lysate (Native) - NBL1-13124 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Mnk2 (h): 293T Lysate - sc-111551 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

MKNK2 Over-expression Lysate Product - GWB-EC97AD from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

MKNK2 Over-expression Lysate Product - GWB-4A7E66 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

MNK2 Overexpression Lysate (Denatured) - H00002872-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human MKNK2 Knockdown Stable Cell Line - CSC-DC009547 from Creative biogene Category Cell Line Species Human

MKNK2 Knockout Cell Line-HEK293T - CSC-RT1958 from Creative biogene Category Cell Line Species Human

MKNK2 KO Cell Lysate-HEK293T - CLKO-1817 from Creative biogene Category Cell Lysate

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