| Gene Symbol |
BCAS2
|
| Entrez Gene |
10286
|
| Alt Symbol |
DAM1, SPF27, Snt309
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
breast carcinoma amplified sequence 2
|
| Other Description |
DNA amplified in mammary carcinoma 1 protein|breast carcinoma-amplified sequence 2|pre-mRNA-splicing factor SPF27|spliceosome associated protein, amplified in breast cancer|spliceosome-associated protein SPF 27
|
| Swissprots |
Q6FGS0 O75934
|
| Accessions |
CAH05197 EAW56602 EAW56603 EAW56604 O75934 AB020623 BAA34863 AB451245 BAG70059 AB451369 BAG70183 AF081788 AAC64059 AK222637 BAD96357 AK313141 BAG35960 BC005285 AAH05285 BC012623 AAH12623 BC022880 AAH22880 BC039238 BF184377 BT019390 AAV38197 CR542037 CAG46834 DQ892529 ABM83455 EU176700 ABW03501 EU832613 ACE87704 EU832684 ACE87016 NM_005872 NP_005863
|
| Function |
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). {ECO:0000269|PubMed:24332808}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:12169396, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:20176811}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:10403562}.
|
| Top Pathways |
Spliceosome
|
![Western Blot: BCAS2 Overexpression Lysate (Adult Normal) [NBL1-07937] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for BCAS2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3935_BCAS2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07937-img0002.jpg)