Gene Symbol | BCAS2 |
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Entrez Gene | 10286 |
Alt Symbol | DAM1, SPF27, Snt309 |
Species | Human |
Gene Type | protein-coding |
Description | breast carcinoma amplified sequence 2 |
Other Description | DNA amplified in mammary carcinoma 1 protein|breast carcinoma-amplified sequence 2|pre-mRNA-splicing factor SPF27|spliceosome associated protein, amplified in breast cancer|spliceosome-associated protein SPF 27 |
Swissprots | Q6FGS0 O75934 |
Accessions | CAH05197 EAW56602 EAW56603 EAW56604 O75934 AB020623 BAA34863 AB451245 BAG70059 AB451369 BAG70183 AF081788 AAC64059 AK222637 BAD96357 AK313141 BAG35960 BC005285 AAH05285 BC012623 AAH12623 BC022880 AAH22880 BC039238 BF184377 BT019390 AAV38197 CR542037 CAG46834 DQ892529 ABM83455 EU176700 ABW03501 EU832613 ACE87704 EU832684 ACE87016 NM_005872 NP_005863 |
Function | Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). {ECO:0000269|PubMed:24332808}. |
Subcellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:12169396, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:20176811}. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:10403562}. |
Top Pathways | Spliceosome |
BCAS2 CRISPR/Cas9 KO Plasmid (h) - sc-405943 from Santa Cruz Biotechnology
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BCAS2 HDR Plasmid (h) - sc-405943-HDR from Santa Cruz Biotechnology
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BCAS2 Double Nickase Plasmid (h) - sc-405943-NIC from Santa Cruz Biotechnology
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BCAS2 Double Nickase Plasmid (h2) - sc-405943-NIC-2 from Santa Cruz Biotechnology
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BCAS2 CRISPR Activation Plasmid (h) - sc-405943-ACT from Santa Cruz Biotechnology
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BCAS2 CRISPR Activation Plasmid (h2) - sc-405943-ACT-2 from Santa Cruz Biotechnology
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BCAS2 Lentiviral Activation Particles (h) - sc-405943-LAC from Santa Cruz Biotechnology
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BCAS2 Lentiviral Activation Particles (h2) - sc-405943-LAC-2 from Santa Cruz Biotechnology
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BCAS2 siRNA (h) - sc-88190 from Santa Cruz Biotechnology
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BCAS2 shRNA Plasmid (h) - sc-88190-SH from Santa Cruz Biotechnology
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BCAS2 shRNA (h) Lentiviral Particles - sc-88190-V from Santa Cruz Biotechnology
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BCAS2 RNAi - H00010286-R01V from Novus Biologicals
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MISSION® esiRNA - EHU108851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3893 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3893 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04215 from Sigma-Aldrich
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BCAS2 siRNA (Human) - CRH6967 from Cohesion Biosciences
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BCAS2 RNAi - H00010286-R01 from Novus Biologicals
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BCAS2 - MBS8204471 from MyBioSource
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BCAS2 CRISPR/Cas9 KO Plasmid (h2) - sc-405943-KO-2 from Santa Cruz Biotechnology
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BCAS2 HDR Plasmid (h2) - sc-405943-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human BCAS2 (NM_005872.2) - SHH245722 from Creative biogene
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shRNA set against Human BCAS2(NM_005872.2) - SHG096041 from Creative biogene
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BCAS2 shRNA Plasmid (Human) - CHH6967 from Cohesion Biosciences
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BCAS2 miRNA 3'UTR clone - MiUTR1H-00828 from Creative biogene
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