COL25A1

Gene Symbol	COL25A1
Entrez Gene	84570
Alt Symbol	AMY, CFEOM5, CLAC, CLAC-P, CLACP
Species	Human
Gene Type	protein-coding
Description	collagen, type XXV, alpha 1
Other Description	alzheimer disease amyloid-associated protein\|collagen alpha-1(XXV) chain\|collagen-like Alzheimer amyloid plaque component\|collagenous Alzheimer amyloid plaque component
Swissprots	Q9BXR9 Q9BXS0 A8MPZ6
Accessions	AAY40947 EAX06238 EAX06239 EAX06240 Q9BXS0 AF293340 AAK35008 AF293341 AAK35009 AK095098 BC030649 BC036669 AAH36669 XM_011532332 XP_011530634 XM_011532333 XP_011530635 XM_011532334 XP_011530636 XM_011532335 XP_011530637 XM_011532336 XP_011530638 XM_011532337 XP_011530639 XM_011532338 XP_011530640 XM_011532339 XP_011530641 XM_011532340 XP_011530642 XM_011532341 XP_011530643 XM_011532342 XP_011530644 XM_011532343 XP_011530645 XM_011532344 XP_011530646 XM_011532345 XP_011530647 XM_011532346 XP_011530648 XM_011532347 XP_011530649 XM_011532348 XP_011530650 XM_011532349 XP_011530651 XM_011532350 XP_011530652 XM_011532351 XP_011530653 XM_011532352 XP_011530654 XM_011532353 XP_011530655 XM_011532354 XP_011530656 XM_011532355 XP_011530657 XM_011532356 XP_011530658 XM_011532357 XP_011530659 XM_011532358 XP_011530660 XM_011532359 XP_011530661 XR_938784 XR_938785 XR_938786 XR_938787 XR_938788 NM_001256074 NP_001243003 NM_032518 NP_115907 NM_198721 NP_942014 NR_045756
Function	Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. {ECO:0000269\|PubMed:15522881, ECO:0000269\|PubMed:15615705, ECO:0000269\|PubMed:15853808, ECO:0000269\|PubMed:16300410}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=After proteolytic cleavage, CLAC is secreted.
Tissue Specificity	Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease. {ECO:0000269\|PubMed:11927537}.

COL25A1 (H-95) - sc-367357 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

COL25A1 (K-14) - sc-46868 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

COL25A1 (K-14): sc-46868. Western blot analysis of COL25A1 expression in U-87 MG (A), T3 671 (B) and HT-1080 (C) whole cell lysates.

COL25A1 (N-16) - sc-46870 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-CLACP antibody - ab33239 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CLACP antibody - ab65159 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-CLACP antibody (ab65159) at 1/500 dilutionLane 1 : Jurkat cell extractLane 2 : A549 cell extractLane 3 : A549 cell extract with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-CLACP antibody - ab167241 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-CLACP antibody (ab167241) at 1/500 dilutionLane 1 : CLACP transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-COL25A1 / Collagen XXV Antibody (aa171-183) - LS-C2632 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-COL25A1 / Collagen XXV Antibody (aa171-183) - LS-C22236 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-COL25A1 / Collagen XXV Antibody (aa155-169) - LS-C40714 from LifeSpan Bioscience

Prices	$275.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-COL25A1 / Collagen XXV Antibody (aa171-183) - LS-C40713 from LifeSpan Bioscience

Prices	$275.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-COL25A1 / Collagen XXV Antibody (aa430-443) - LS-C40715 from LifeSpan Bioscience

Prices	$275.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-COL25A1 / Collagen XXV Antibody (aa189-654) - LS-C143710 from LifeSpan Bioscience

Prices	$465.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-COL25A1 / Collagen XXV Antibody (aa189-654) - LS-C79680 from LifeSpan Bioscience

Prices	$605.00
Sizes	100 µg
Host	Sheep
Clonality	Polyclonal

Anti-COL25A1 / Collagen XXV Antibody - LS-C153062 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-COL25A1 / Collagen XXV Antibody (aa57-123) - LS-C307034 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-COL25A1 / Collagen XXV Antibody (aa430-443) IHC-plus™ - LS-B664 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-COL25A1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B664 concentration 5 ug/ml.

Anti-COL25A1 / Collagen XXV Antibody (aa362-411) - LS-C81514 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-COL25A1 / Collagen XXV Antibody (aa101-150) - LS-C119476 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of extracts from Jurkat/A549 cells, using Collagen XXV alpha1 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-COL25A1 / Collagen XXV Antibody (aa155-169) IHC-plus™ - LS-B663 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Collagen XXV alpha 1 Antibody - AF4317 from Novus Biologicals

Prices	$99.00, $359.00
Sizes	25 µg, 100 µg
Host	Sheep
Clonality	Polyclonal

Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line and HEK293 human embryonic kidney cell line. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human Collagen XXV alpha 1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4317) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for Collagen XXV alpha 1 at approximately 65 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

Collagen XXV alpha 1 Antibody (540802) - MAB4317 from Novus Biologicals

Prices	$99.00, $249.00
Sizes	25 µg, 100 µg
Host	Mouse
Clonality	Monoclonal
Clone	540802

Collagen XXV alpha 1 Antibody - NB300-289 from Novus Biologicals

Prices	$229.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: Collagen XXV alpha 1 Antibody [NB300-289] - Stable HEK293 cell line expressing CLAC-P using NB300-289. Lane 1: full-length CLAC-P (lysate). Lane 2: secreted form of CLAC-P (media). Lane 3: COLXIII (lysate). Lane 4 degrees COLXIII (media). Lane 5: COLXXIII (lysate). Lane 6: COLXXIII (media).

Collagen XXV alpha 1 Antibody - NBP1-60039 from Novus Biologicals

Prices	$139.00, $329.00
Sizes	20 µl, 100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: Collagen XXV Antibody [NBP1-60039] - Jurkat cell lysate, concentration 0.2-1 ug/ml.

Collagen XXV alpha 1 Antibody - NB300-248 from Novus Biologicals

Prices	$229.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Collagen XXV alpha 1 Antibody - NB300-249 from Novus Biologicals

Prices	$229.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: Collagen XXV Antibody [NB300-249] - Analysis of Collagen XXV, using Img-4153 and IMG-4154 at 1:500 dilution on 100 ug of formic acid extracts of Alzheimer diseased brain.

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