| Gene Symbol | COL25A1 |
|---|---|
| Entrez Gene | 84570 |
| Alt Symbol | AMY, CFEOM5, CLAC, CLAC-P, CLACP |
| Species | Human |
| Gene Type | protein-coding |
| Description | collagen, type XXV, alpha 1 |
| Other Description | alzheimer disease amyloid-associated protein|collagen alpha-1(XXV) chain|collagen-like Alzheimer amyloid plaque component|collagenous Alzheimer amyloid plaque component |
| Swissprots | Q9BXR9 Q9BXS0 A8MPZ6 |
| Accessions | AAY40947 EAX06238 EAX06239 EAX06240 Q9BXS0 AF293340 AAK35008 AF293341 AAK35009 AK095098 BC030649 BC036669 AAH36669 XM_011532332 XP_011530634 XM_011532333 XP_011530635 XM_011532334 XP_011530636 XM_011532335 XP_011530637 XM_011532336 XP_011530638 XM_011532337 XP_011530639 XM_011532338 XP_011530640 XM_011532339 XP_011530641 XM_011532340 XP_011530642 XM_011532341 XP_011530643 XM_011532342 XP_011530644 XM_011532343 XP_011530645 XM_011532344 XP_011530646 XM_011532345 XP_011530647 XM_011532346 XP_011530648 XM_011532347 XP_011530649 XM_011532348 XP_011530650 XM_011532349 XP_011530651 XM_011532350 XP_011530652 XM_011532351 XP_011530653 XM_011532352 XP_011530654 XM_011532353 XP_011530655 XM_011532354 XP_011530656 XM_011532355 XP_011530657 XM_011532356 XP_011530658 XM_011532357 XP_011530659 XM_011532358 XP_011530660 XM_011532359 XP_011530661 XR_938784 XR_938785 XR_938786 XR_938787 XR_938788 NM_001256074 NP_001243003 NM_032518 NP_115907 NM_198721 NP_942014 NR_045756 |
| Function | Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. {ECO:0000269|PubMed:15522881, ECO:0000269|PubMed:15615705, ECO:0000269|PubMed:15853808, ECO:0000269|PubMed:16300410}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=After proteolytic cleavage, CLAC is secreted. |
| Tissue Specificity | Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease. {ECO:0000269|PubMed:11927537}. |
COL25A1 CRISPR/Cas9 KO Plasmid (h) - sc-413669 from Santa Cruz Biotechnology
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COL25A1 HDR Plasmid (h) - sc-413669-HDR from Santa Cruz Biotechnology
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COL25A1 Double Nickase Plasmid (h) - sc-413669-NIC from Santa Cruz Biotechnology
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COL25A1 Double Nickase Plasmid (h2) - sc-413669-NIC-2 from Santa Cruz Biotechnology
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COL25A1 CRISPR Activation Plasmid (h) - sc-413669-ACT from Santa Cruz Biotechnology
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COL25A1 CRISPR Activation Plasmid (h2) - sc-413669-ACT-2 from Santa Cruz Biotechnology
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COL25A1 Lentiviral Activation Particles (h) - sc-413669-LAC from Santa Cruz Biotechnology
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COL25A1 Lentiviral Activation Particles (h2) - sc-413669-LAC-2 from Santa Cruz Biotechnology
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COL25A1 siRNA (h) - sc-60429 from Santa Cruz Biotechnology
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COL25A1 shRNA Plasmid (h) - sc-60429-SH from Santa Cruz Biotechnology
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COL25A1 shRNA (h) Lentiviral Particles - sc-60429-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU157851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6384 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6384 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01280 from Sigma-Aldrich
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COL25A1 siRNA (Human) - CRJ3528 from Cohesion Biosciences
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COL25A1 - MBS8223389 from MyBioSource
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shRNA set against Human COL25A1 (NM_198721.2) - SHH267213 from Creative biogene
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shRNA set against Human COL25A1(NM_032518.2) - SHG190027 from Creative biogene
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Human COL25A1 siRNA - orb274029 from Biorbyt
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COL25A1 shRNA Plasmid (Human) - CHJ3528 from Cohesion Biosciences
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COL25A1 miRNA 3'UTR clone - MiUTR3H-10951 from Creative biogene
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COL25A1 miRNA 3'UTR clone - MiUTR3H-10952 from Creative biogene
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