| Gene Symbol |
UBE2K
|
| Entrez Gene |
3093
|
| Alt Symbol |
E2-25K, HIP2, HYPG, LIG, UBC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2K
|
| Other Description |
E2(25K)|HIP-2|huntingtin interacting protein 2|huntingtin-interacting protein 2|ubiquitin carrier protein|ubiquitin-conjugating enzyme E2 K|ubiquitin-conjugating enzyme E2(25K)|ubiquitin-conjugating enzyme E2-25 KDA|ubiquitin-conjugating enzyme E2-25K|ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)|ubiquitin-protein ligase
|
| Swissprots |
B2RDF8 Q9Y2D3 P61086 P27924 A8K5Y9 Q9CVV9 A6NJC1 C9JGP1 O54806 Q16721
|
| Accessions |
EAW92946 EAW92947 EAW92948 EAW92949 EAW92950 P61086 AB022435 BAA78555 AB022436 BAA78556 AK093533 BAG52736 AK291454 BAF84143 AK295846 BAG58654 AK307130 AK315524 BAG37905 AL117568 BC022804 AAH22804 BC050600 AAH50600 BU622273 BX641089 CX786829 DA526283 EU446896 ABZ92425 U58522 AAC50633 NM_001111112 NP_001104582 NM_001111113 NP_001104583 NM_005339 NP_005330
|
| Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In c
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Expressed in all tissues tested, including spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes and bone marrow mononuclear cells. Highly expressed in brain, with highest levels found in cortex and striatum and at lower levels in cerebellum and brainstem. {ECO:0000269|PubMed:10634809, ECO:0000269|PubMed:10675012, ECO:0000269|PubMed:8702625}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|
![Western Blot: HIP2 Overexpression Lysate (Adult Normal) [NBL1-17536] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HIP2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2679_HIP2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17536-img0002.jpg)