UBE2K

Gene Symbol	UBE2K
Entrez Gene	3093
Alt Symbol	E2-25K, HIP2, HYPG, LIG, UBC1
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2K
Other Description	E2(25K)|HIP-2|huntingtin interacting protein 2|huntingtin-interacting protein 2|ubiquitin carrier protein|ubiquitin-conjugating enzyme E2 K|ubiquitin-conjugating enzyme E2(25K)|ubiquitin-conjugating enzyme E2-25 KDA|ubiquitin-conjugating enzyme E2-25K|ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)|ubiquitin-protein ligase
Swissprots	B2RDF8 Q9Y2D3 P61086 P27924 A8K5Y9 Q9CVV9 A6NJC1 C9JGP1 O54806 Q16721
Accessions	EAW92946 EAW92947 EAW92948 EAW92949 EAW92950 P61086 AB022435 BAA78555 AB022436 BAA78556 AK093533 BAG52736 AK291454 BAF84143 AK295846 BAG58654 AK307130 AK315524 BAG37905 AL117568 BC022804 AAH22804 BC050600 AAH50600 BU622273 BX641089 CX786829 DA526283 EU446896 ABZ92425 U58522 AAC50633 NM_001111112 NP_001104582 NM_001111113 NP_001104583 NM_005339 NP_005330
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In c
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	Expressed in all tissues tested, including spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes and bone marrow mononuclear cells. Highly expressed in brain, with highest levels found in cortex and striatum and at lower levels in cerebellum and brainstem. {ECO:0000269|PubMed:10634809, ECO:0000269|PubMed:10675012, ECO:0000269|PubMed:8702625}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HIP2 CRISPR/Cas9 KO Plasmid (h) - sc-409627 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HIP2 HDR Plasmid (h) - sc-409627-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HIP2 Double Nickase Plasmid (h) - sc-409627-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HIP2 Double Nickase Plasmid (h2) - sc-409627-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HIP2 CRISPR Activation Plasmid (h) - sc-409627-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HIP2 CRISPR Activation Plasmid (h2) - sc-409627-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HIP2 Lentiviral Activation Particles (h) - sc-409627-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HIP2 Lentiviral Activation Particles (h2) - sc-409627-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HIP2 siRNA (h) - sc-41984 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HIP2 shRNA Plasmid (h) - sc-41984-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HIP2 shRNA (h) Lentiviral Particles - sc-41984-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HIP2 RNAi - H00003093-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU091111 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22370 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22370 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09882 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr09882

UBE2K siRNA (Human) - CRH2107 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

UBE2K - MBS8228192 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human UBE2K (NM_005339.4) - SHH439044 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human HIP2(NM_005339.4) - SHL111324 from Creative biogene Category siRNA Species Reactivities Human

Human UBE2K siRNA - orb262609 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

UBE2K shRNA Plasmid (Human) - CHH2107 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

UBE2K miRNA 3'UTR clone - MiUTR1H-04506 from Creative biogene Species Reactivities Human

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