UBE2K

Gene Symbol	UBE2K
Entrez Gene	3093
Alt Symbol	E2-25K, HIP2, HYPG, LIG, UBC1
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2K
Other Description	E2(25K)|HIP-2|huntingtin interacting protein 2|huntingtin-interacting protein 2|ubiquitin carrier protein|ubiquitin-conjugating enzyme E2 K|ubiquitin-conjugating enzyme E2(25K)|ubiquitin-conjugating enzyme E2-25 KDA|ubiquitin-conjugating enzyme E2-25K|ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)|ubiquitin-protein ligase
Swissprots	B2RDF8 Q9Y2D3 P61086 P27924 A8K5Y9 Q9CVV9 A6NJC1 C9JGP1 O54806 Q16721
Accessions	EAW92946 EAW92947 EAW92948 EAW92949 EAW92950 P61086 AB022435 BAA78555 AB022436 BAA78556 AK093533 BAG52736 AK291454 BAF84143 AK295846 BAG58654 AK307130 AK315524 BAG37905 AL117568 BC022804 AAH22804 BC050600 AAH50600 BU622273 BX641089 CX786829 DA526283 EU446896 ABZ92425 U58522 AAC50633 NM_001111112 NP_001104582 NM_001111113 NP_001104583 NM_005339 NP_005330
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In c
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	Expressed in all tissues tested, including spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes and bone marrow mononuclear cells. Highly expressed in brain, with highest levels found in cortex and striatum and at lower levels in cerebellum and brainstem. {ECO:0000269|PubMed:10634809, ECO:0000269|PubMed:10675012, ECO:0000269|PubMed:8702625}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HIP2 full length protein - ab156061 from Abcam Category Protein Source E. coli Species Human

Human HIP2 full length protein - ab127407 from Abcam Category Protein Source E. coli Species Human

Human HIP2 full length protein - ab185387 from Abcam Category Protein Source E. coli Species Human

Human HIP2 full length protein - ab127401 from Abcam Category Protein Source E. coli Species Human

Human HIP2 full length protein - ab111465 from Abcam Category Protein Source E. coli Species Human

Human HIP2 full length protein - ab73665 from Abcam Category Protein Source E. coli Species Human

UBE2K / LIG Antibody Blocking Peptide - LS-E25469 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2K / LIG Antibody Blocking Peptide - LS-E15843 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2K / LIG Antibody Blocking Peptide - LS-E15844 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2K / LIG Antibody Blocking Peptide - LS-E21221 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2K / LIG Antibody Blocking Peptide - LS-E21222 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human UBE2K/E2-25K His Protein - NBP2-35096 from Novus Biologicals Category Protein Prices $69.00, $169.00, $1,969.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli Species Human

HIP2 Recombinant Protein - H00003093-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human HIP2 Protein - NBP1-50974 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E. coli Species Human

Recombinant Human UBE2K/E2-25K, CF - E2-603-050 from R&D Systems Category Protein Source E. coli-derived,

Recombinant Human UBE2K/E2-25K, CF - E2-603-100 from R&D Systems Category Protein Source E. coli-derived,

Recombinant Human UBE2K/E2-25K, CF - SP-200-050 from R&D Systems Category Protein Source E. coli-derived,

Recombinant Human UBE2K/E2-25K Biotinylated, CF - SP-205-025 from R&D Systems Category Protein

Recombinant human Ubiquitin-conjugating enzyme E2 K (OPCA00828) - OPCA00828 from Aviva Systems Biology Category Protein Prices $198.00 Sizes 50 µg Species Human

UBE2K Protein (OPPA00856) - OPPA00856 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human UBC1 protein - orb107811 from Biorbyt Category Protein Prices $221.00, $357.00, $425.00, $629.00 Sizes 10 μg, 50 μg, 100 μg, 250 μg Source E.coli Species Human

Human UBE2K protein - orb180453 from Biorbyt Category Protein Prices $179.00, $289.00, $791.00, $1,207.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source E.coli Species Human

Human UBE2K protein - orb90296 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E.coli Species Human

Human UBE2K protein - orb245434 from Biorbyt Category Protein Prices $315.00, $502.00, $782.00, $1,139.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human UBE2K protein - orb49718 from Biorbyt Category Protein Prices $179.00, $264.00, $825.00, $1,148.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Search more