| Gene Symbol |
IL22RA2
|
| Entrez Gene |
116379
|
| Alt Symbol |
CRF2-10, CRF2-S1, CRF2X, IL-22BP, IL-22R-alpha-2, IL-22RA2, ZCYTOR16
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interleukin 22 receptor, alpha 2
|
| Other Description |
cytokine receptor class-II member 10|cytokine receptor family type 2, soluble 1|interleukin 22-binding protein|interleukin-22 receptor subunit alpha-2
|
| Swissprots |
Q6UWM1 Q969J5 Q96A41 Q08AH7 Q96QR0
|
| Accessions |
AAV31775 CAH61626 CAH61631 CAL60107 CAP40188 CBM42925 EAW47933 EAW47934 EAW47935 Q969J5 AI824338 AJ297262 CAC83097 AJ313161 CAC85634 AJ313162 CAC85635 AY040566 AAK85714 AY040567 AAK85715 AY040568 AAK85716 AY044429 AAK91775 AY358111 AAQ88478 AY358737 AAQ89097 BC125167 AAI25168 BC125168 AAI25169 NM_052962 NP_443194 NM_181309 NP_851826 NM_181310 NP_851827
|
| Function |
Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:12700595}.
|
| Tissue Specificity |
Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach. {ECO:0000269|PubMed:11481447, ECO:0000269|PubMed:11607789, ECO:0000269|PubMed:15201862}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
|
![Western Blot: IL22 RA2 Overexpression Lysate (Adult Normal) [NBL1-11942] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IL22 RA2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7948_IL22%2520RA2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11942-img0002.jpg)