IL22RA2
| Gene Symbol | IL22RA2 |
|---|---|
| Entrez Gene | 116379 |
| Alt Symbol | CRF2-10, CRF2-S1, CRF2X, IL-22BP, IL-22R-alpha-2, IL-22RA2, ZCYTOR16 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 22 receptor, alpha 2 |
| Other Description | cytokine receptor class-II member 10|cytokine receptor family type 2, soluble 1|interleukin 22-binding protein|interleukin-22 receptor subunit alpha-2 |
| Swissprots | Q6UWM1 Q969J5 Q96A41 Q08AH7 Q96QR0 |
| Accessions | AAV31775 CAH61626 CAH61631 CAL60107 CAP40188 CBM42925 EAW47933 EAW47934 EAW47935 Q969J5 AI824338 AJ297262 CAC83097 AJ313161 CAC85634 AJ313162 CAC85635 AY040566 AAK85714 AY040567 AAK85715 AY040568 AAK85716 AY044429 AAK91775 AY358111 AAQ88478 AY358737 AAQ89097 BC125167 AAI25168 BC125168 AAI25169 NM_052962 NP_443194 NM_181309 NP_851826 NM_181310 NP_851827 |
| Function | Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:12700595}. |
| Tissue Specificity | Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach. {ECO:0000269|PubMed:11481447, ECO:0000269|PubMed:11607789, ECO:0000269|PubMed:15201862}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
IL-22Rα2 CRISPR/Cas9 KO Plasmid (h) - sc-404981 from Santa Cruz Biotechnology
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IL-22Rα2 HDR Plasmid (h) - sc-404981-HDR from Santa Cruz Biotechnology
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IL-22Rα2 Double Nickase Plasmid (h) - sc-404981-NIC from Santa Cruz Biotechnology
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IL-22Rα2 Double Nickase Plasmid (h2) - sc-404981-NIC-2 from Santa Cruz Biotechnology
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IL-22Rα2 CRISPR Activation Plasmid (h) - sc-404981-ACT from Santa Cruz Biotechnology
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IL-22Rα2 CRISPR Activation Plasmid (h2) - sc-404981-ACT-2 from Santa Cruz Biotechnology
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IL-22Rα2 Lentiviral Activation Particles (h) - sc-404981-LAC from Santa Cruz Biotechnology
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IL-22Rα2 Lentiviral Activation Particles (h2) - sc-404981-LAC-2 from Santa Cruz Biotechnology
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IL-22Rα2 siRNA (h) - sc-62495 from Santa Cruz Biotechnology
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IL-22Rα2 shRNA Plasmid (h) - sc-62495-SH from Santa Cruz Biotechnology
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IL-22Rα2 shRNA (h) Lentiviral Particles - sc-62495-V from Santa Cruz Biotechnology
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IL-22BP/IL22 RA2 RNAi - H00116379-R06 from Novus Biologicals
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IL-22BP/IL22 RA2 RNAi - H00116379-R05 from Novus Biologicals
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MISSION® esiRNA - EHU092481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10611 from Sigma-Aldrich
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IL22RA2 siRNA (Human) - CRJ4512 from Cohesion Biosciences
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IL-22BP/IL22 RA2 RNAi - H00116379-R04 from Novus Biologicals
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IL22RA2 - MBS8209631 from MyBioSource
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shRNA set against Human Il22ra2 (NM_052962.2) - SHH318737 from Creative biogene
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shRNA set against Human IL22RA2(NM_052962.2) - SHL134886 from Creative biogene
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shRNA set against Human IL22RA2(NM_181310.1) - SHL134888 from Creative biogene
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shRNA set against Human IL22RA2(NM_052962.2) - SHL134889 from Creative biogene
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shRNA set against Human IL22RA2(NM_181310.1) - SHL134890 from Creative biogene
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shRNA set against Human IL22RA2(NM_052962.2) - SHL134891 from Creative biogene
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