IL22RA2
| Gene Symbol | IL22RA2 |
|---|---|
| Entrez Gene | 116379 |
| Alt Symbol | CRF2-10, CRF2-S1, CRF2X, IL-22BP, IL-22R-alpha-2, IL-22RA2, ZCYTOR16 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 22 receptor, alpha 2 |
| Other Description | cytokine receptor class-II member 10|cytokine receptor family type 2, soluble 1|interleukin 22-binding protein|interleukin-22 receptor subunit alpha-2 |
| Swissprots | Q6UWM1 Q969J5 Q96A41 Q08AH7 Q96QR0 |
| Accessions | AAV31775 CAH61626 CAH61631 CAL60107 CAP40188 CBM42925 EAW47933 EAW47934 EAW47935 Q969J5 AI824338 AJ297262 CAC83097 AJ313161 CAC85634 AJ313162 CAC85635 AY040566 AAK85714 AY040567 AAK85715 AY040568 AAK85716 AY044429 AAK91775 AY358111 AAQ88478 AY358737 AAQ89097 BC125167 AAI25168 BC125168 AAI25169 NM_052962 NP_443194 NM_181309 NP_851826 NM_181310 NP_851827 |
| Function | Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:12700595}. |
| Tissue Specificity | Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach. {ECO:0000269|PubMed:11481447, ECO:0000269|PubMed:11607789, ECO:0000269|PubMed:15201862}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
Human IL22 RA2 full length protein - ab127150 from Abcam
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IL-22BP / IL22RA2 Antibody Blocking Peptide - LS-E5993 from LifeSpan Bioscience
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IL-22BP / IL22RA2 Antibody Blocking Peptide - LS-E23866 from LifeSpan Bioscience
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IL22RA2-Antibody-N-term-Blocking-Peptide - BP18561a from Abgent, a WuXi AppTec company
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Recombinant Mouse IL-22BP Fc Chimera, CF - 2376-BP-025 from R&D Systems
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Recombinant Human IL-22BP Fc Chimera, CF - 1087-BP-025 from R&D Systems
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IL-22RA2 Blocking Peptide - abx064039 from Abbexa
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IL22RA2 fusion protein - ag18854 from Proteintech Group
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IL22RA2 fusion protein - ag18682 from Proteintech Group
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Recombinant Human IL22RA2, His tagged - IL22RA2-2258H from Creative Biomart
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Recombinant Human IL22RA2, Fc-His tagged - IL22RA2-2259H from Creative Biomart
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Recombinant Human IL22RA2, Fc Chimera - IL22RA2-870H from Creative Biomart
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Recombinant Interleukin 22 Receptor Alpha 2 (IL22Ra2) - RPE767Hu01 from Uscn Life Science Inc.
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Recombinant Interleukin 22 Receptor Alpha 2 (IL22Ra2) - RPE767Mu01 from Uscn Life Science Inc.
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Recombinant Interleukin 22 Receptor Alpha 2 (IL22Ra2) - RPE767Mu02 from Uscn Life Science Inc.
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Recombinant Interleukin 22 Receptor Alpha 2 (IL22Ra2) - RPE767Ra01 from Uscn Life Science Inc.
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Human IL22BP / IL22RA2 Protein (His Tag) - 11025-H08H-20 from Sino Biological
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Human IL22BP / IL22RA2 Protein (His & Fc Tag) - 11025-H03H-50 from Sino Biological
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IL-22RA2 Blocking Peptide - CBP2845 from Cohesion Biosciences
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IL-22Rα2 Peptide - BS60293P from Bioworld Technology
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Recombinant Interleukin 22 Receptor Alpha 2 (IL22Ra2) - RPE767Hu01 from Cloud-clone
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Recombinant Human Interleukin-22 receptor subunit alpha-2(IL22RA2) - CSB-YP850247HU CSB-EP850247HU CSB-BP850247HU CSB-MP850247HU from Cusabio
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Recombinant Human IL-22BP Fc Chimera Protein, CF - 1087-BP from R&D Systems
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Recombinant Mouse IL-22BP Fc Chimera Protein, CF - 2376-BP from R&D Systems
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IL22RA2 Protein - abx164303 from Abbexa
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