| Gene Symbol |
RAB43
|
| Entrez Gene |
339122
|
| Alt Symbol |
RAB11B, RAB41
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB43, member RAS oncogene family
|
| Other Description |
ras-related protein Rab-41|ras-related protein Rab-43
|
| Swissprots |
Q86YS6 E9PBQ0 A8K4P9
|
| Accessions |
EAW79283 Q86YS6 AK128345 AK291014 BAF83703 AY166852 AAO17291 BC062319 AAH62319 BC073812 BX331971 CA450364 D45418 DA008447 DA103180 DA317502 DA339537 DA757569 DB220260 NM_001204883 NP_001191812 NM_001204884 NP_001191813 NM_001204885 NP_001191814 NM_001204886 NP_001191815 NM_001204887 NP_001191816 NM_001204888 NP_001191817 NM_198490 NP_940892
|
| Function |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. {ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057, ECO:0000269|PubMed:18664496, ECO:0000269|PubMed:21255211}.
|
| Subcellular Location |
Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Golgi apparatus, trans-Golgi network. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.
|
| Tissue Specificity |
Widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in liver. {ECO:0000269|PubMed:15018353}.
|