RAB43

Gene Symbol RAB43
Entrez Gene 339122
Alt Symbol RAB11B, RAB41
Species Human
Gene Type protein-coding
Description RAB43, member RAS oncogene family
Other Description ras-related protein Rab-41|ras-related protein Rab-43
Swissprots Q86YS6 E9PBQ0 A8K4P9
Accessions EAW79283 Q86YS6 AK128345 AK291014 BAF83703 AY166852 AAO17291 BC062319 AAH62319 BC073812 BX331971 CA450364 D45418 DA008447 DA103180 DA317502 DA339537 DA757569 DB220260 NM_001204883 NP_001191812 NM_001204884 NP_001191813 NM_001204885 NP_001191814 NM_001204886 NP_001191815 NM_001204887 NP_001191816 NM_001204888 NP_001191817 NM_198490 NP_940892
Function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. {ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057, ECO:0000269|PubMed:18664496, ECO:0000269|PubMed:21255211}.
Subcellular Location Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Golgi apparatus, trans-Golgi network. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.
Tissue Specificity Widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in liver. {ECO:0000269|PubMed:15018353}.

Rab 43 CRISPR/Cas9 KO Plasmid (h) - sc-417535 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 43 HDR Plasmid (h) - sc-417535-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 43 Double Nickase Plasmid (h) - sc-417535-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 43 Double Nickase Plasmid (h2) - sc-417535-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 43 CRISPR Activation Plasmid (h) - sc-417535-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 43 CRISPR Activation Plasmid (h2) - sc-417535-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 43 Lentiviral Activation Particles (h) - sc-417535-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 43 Lentiviral Activation Particles (h2) - sc-417535-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 43 siRNA (h) - sc-78238 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rab 43 shRNA Plasmid (h) - sc-78238-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rab 43 shRNA (h) Lentiviral Particles - sc-78238-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RAB43 RNAi - H00339122-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU094061 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU100391 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17856 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17856 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

RAB43 siRNA (Human) - CRJ7267 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RAB43 - MBS8223901 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RAB43 (NM_198490.2) - SHH388436 from Creative biogene

Category siRNA
Species Reactivities Human

RAB43 shRNA Plasmid (Human) - CHJ7267 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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