RAB43

Gene Symbol	RAB43
Entrez Gene	339122
Alt Symbol	RAB11B, RAB41
Species	Human
Gene Type	protein-coding
Description	RAB43, member RAS oncogene family
Other Description	ras-related protein Rab-41|ras-related protein Rab-43
Swissprots	Q86YS6 E9PBQ0 A8K4P9
Accessions	EAW79283 Q86YS6 AK128345 AK291014 BAF83703 AY166852 AAO17291 BC062319 AAH62319 BC073812 BX331971 CA450364 D45418 DA008447 DA103180 DA317502 DA339537 DA757569 DB220260 NM_001204883 NP_001191812 NM_001204884 NP_001191813 NM_001204885 NP_001191814 NM_001204886 NP_001191815 NM_001204887 NP_001191816 NM_001204888 NP_001191817 NM_198490 NP_940892
Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. {ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057, ECO:0000269|PubMed:18664496, ECO:0000269|PubMed:21255211}.
Subcellular Location	Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Golgi apparatus, trans-Golgi network. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.
Tissue Specificity	Widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in liver. {ECO:0000269|PubMed:15018353}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RAB43 full length protein - ab166258 from Abcam Category Protein Source Wheat germ Species Human

Human RAB43 protein fragment - ab166259 from Abcam Category Protein Source Wheat germ Species Human

RAB41 Antibody Blocking Peptide - LS-E4230 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAB41 Antibody Blocking Peptide - LS-E24187 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RAB43 Protein - H00339122-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human RAB43 Protein - H00339122-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RAB43 - H00339122-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RAB43 - H00339122-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RAB43 - H00339122-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RAB43 - H00339122-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RAB43 fusion protein - Ag10260 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

RAB43 fusion protein - Ag10277 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human RAB43, His-tagged - RAB43-2128H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Ras-related protein Rab-43(RAB43) - CSB-YP773063HU CSB-EP773063HU CSB-BP773063HU CSB-MP773063HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RAB43 - TP309159 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RAB43 Recombinant Protein Antigen - NBP2-49309PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

RAB41 Recombinant Protein Antigen - NBP1-86528PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RAB41 Peptide, Human - M34GP12866H from Creative Peptides Category Peptide Source Synthetic. Species Human

RAB43 Peptide, Human - M34GP12868H from Creative Peptides Category Peptide Source Synthetic. Species Human

Ras-related protein Rab-43 (RAB43), Recombinant Protein - MBS1432170 from MyBioSource Category Protein Prices $960.00, $960.00, $1,185.00, $1,185.00, $1,445.00, $1,445.00, $1,910.00, $1,910.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RAB43 fusion protein - Ag26911 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

RAB41 peptide - orb304779 from Biorbyt Category Peptide

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