STUB1

Gene Symbol	STUB1
Entrez Gene	10273
Alt Symbol	CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1
Species	Human
Gene Type	protein-coding
Description	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Other Description	CLL-associated antigen KW-8|E3 ubiquitin-protein ligase CHIP|antigen NY-CO-7|carboxy terminus of Hsp70-interacting protein|heat shock protein A binding protein 2 (c-terminal)|serologically defined colon cancer antigen 7
Swissprots	O60526 Q969U2 A2IDB9 Q9HBT1 Q9UNE7
Accessions	AAK61242 CAV30716 EAW85756 EAW85757 EAW85758 Q9UNE7 AF039689 AAC18038 AF129085 AAD33400 AF217968 AAG17211 AF432221 AAL99927 BC007545 AAH07545 BC017178 AAH17178 BC022788 AAH22788 BC063617 AAH63617 CB145452 DQ893185 ABM84111 DQ896502 ABM87501 NM_001293197 NP_001280126 NM_005861 NP_005852
Function	E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF- BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Negatively regu
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:23973223}. Nucleus {ECO:0000269|PubMed:23973223}. Note=Translocates to the nucleus in response to inflammatory signals in regulatory T-cells (Treg). {ECO:0000269|PubMed:23973223}.
Tissue Specificity	Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung. {ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:11435423}.
Top Pathways	Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rabbit anti-STUB1/CHIP Antibody, Affinity Purified - PLA0196 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Mouse STUB1 / CHIP ELISA Kit (Sandwich ELISA) - LS-F9065 from LifeSpan Bioscience Category ELISA Kit Prices $810.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 0.156-10 ng/ml

Human CHIP Ubiquitin Ligase Kit - Glow-Fold Substrate - K-280 from R&D Systems Category ChIP Kit Prices $455.00 Sizes 1 kit

E3 ubiquitin-protein ligase CHIP (STUB1), Human, ELISA Kit - CSB-EL022887HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 5.8 pg/ml Range 23.5 pg/ml-1500 pg/ml

Human STUB1(E3 ubiquitin-protein ligase CHIP) ELISA Kit - E-EL-H5533 from Elabscience Category ELISA Kit Sensitivity 18.75 pg/mL Range 31.25—2000 pg/mL

STIP1 homology and U-box containing protein 1, ELISA Kit - MBS943764 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human STUB1 is typically less than 5.8 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 23.5 pg/ml -1500 pg/ml.

STIP1 Homology And U-Box Containing Protein 1 (STUB1), ELISA Kit - MBS2020316 from MyBioSource Category ELISA Kit Prices $420.00, $625.00, $855.00, $3,510.00, $6,365.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.059ng/mL. Range 0.156-10ng/mL

STUB1, ELISA Kit - MBS2515834 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Human STUB1 is 18.75pg/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 31.25-2000pg/mL

ELISA Kit for STIP1 Homology And U-Box Containing Protein 1 (STUB1) - SEL085Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human E3 ubiquitin-protein ligase CHIP(STUB1) ELISA kit - CSB-EL022887HU from Cusabio Category ELISA Kit Sensitivity 5.8 pg/ml Range 23.5 pg/ml-1500 pg/ml

HumanSTUB1(E3ubiquitin-proteinligaseCHIP) ELISAKit - E-EL-H5533 from Iwai North America Inc. Category ChIP Kit Prices $580.00 Sizes 1 kit Sensitivity 18.75 pg/mL Range 31.25~2000 pg/mL

STUB1 - EKH7666 from Nordic BioSite Sensitivity 18.75pg/ml Range 31.25-2000pg/ml

Custom Human CHIP ELISA - ELH-CHIP-1 from RayBiotech Category ELISA Kit Prices $627.00, $1,128.60, $2,508.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human STUB1 ELISA Kit - E012644 from Biobool Category ELISA Kit

STUB1 ELISA Kit (Human) (OKEH03277) - OKEH03277 from Aviva Systems Biology Category ELISA Kit Prices $425.00 Sizes 96 wells Sensitivity 0.156 ng/mL Range 0.312 - 20 ng/mL

Human E3 ubiquitin-protein ligase CHIP ELISA Kit - EK4512 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Range 78-5000 pg/mL

Custom Human CHIP ELISA Kit - orb384513 from Biorbyt Category ELISA Kit Prices $1,479.00, $2,572.00, $5,578.00 Sizes 96 assays, 192 assays, 480 assays

anti-STUB1 / CHIP antibody - ARG55424 from Arigo Biolaboratories Category ELISA Kit

anti-STUB1 / CHIP antibody - ARG55429 from Arigo Biolaboratories Category ELISA Kit

anti-STUB1 / CHIP antibody - ARG63584 from Arigo Biolaboratories Category ELISA Kit

Human E3 ubiquitin-protein ligase CHIP (STUB1) ELISA Kit - AE15752HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.059 ng/mL Range 0.156-10 ng/mL

E3 ubiquitin-protein ligase CHIP, ELISA Kit - MBS285803 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 ubiquitin-protein ligase CHIP, ELISA Kit - MBS9428338 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Range 0.312-20 ng/mL

E3 ubiquitin-protein ligase CHIP, ELISA Kit - MBS2887813 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.312-20 ng/ml

E3 ubiquitin-protein ligase CHIP, ELISA Kit - MBS765273 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 18.75pg/ml Range 31.25-2000pg/ml

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