STUB1

Gene Symbol	STUB1
Entrez Gene	10273
Alt Symbol	CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1
Species	Human
Gene Type	protein-coding
Description	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Other Description	CLL-associated antigen KW-8|E3 ubiquitin-protein ligase CHIP|antigen NY-CO-7|carboxy terminus of Hsp70-interacting protein|heat shock protein A binding protein 2 (c-terminal)|serologically defined colon cancer antigen 7
Swissprots	O60526 Q969U2 A2IDB9 Q9HBT1 Q9UNE7
Accessions	AAK61242 CAV30716 EAW85756 EAW85757 EAW85758 Q9UNE7 AF039689 AAC18038 AF129085 AAD33400 AF217968 AAG17211 AF432221 AAL99927 BC007545 AAH07545 BC017178 AAH17178 BC022788 AAH22788 BC063617 AAH63617 CB145452 DQ893185 ABM84111 DQ896502 ABM87501 NM_001293197 NP_001280126 NM_005861 NP_005852
Function	E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF- BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Negatively regu
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:23973223}. Nucleus {ECO:0000269|PubMed:23973223}. Note=Translocates to the nucleus in response to inflammatory signals in regulatory T-cells (Treg). {ECO:0000269|PubMed:23973223}.
Tissue Specificity	Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung. {ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:11435423}.
Top Pathways	Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CHIP (C3B6) Rabbit mAb - 2080 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone C3B6

CHIP (C-10) - sc-133083 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

CHIP (G-2) - sc-133066 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

CHIP (H-231) - sc-66830 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

CHIP (N-13) - sc-33265 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CHIP (I-16) - sc-33264 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-STUB1 antibody - ab129295 from Abcam Prices $378.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-STUB1 antibody - ab2482 from Abcam Prices $378.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-STUB1 antibody - ab80058 from Abcam Prices $370.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STUB1 antibody [EPR4447] - ab134064 from Abcam Prices $394.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4447

Anti-STUB1 antibody [EPR4448] - ab109103 from Abcam Prices $381.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4448

Anti-STUB1 / CHIP Antibody (aa243-271, Biotin) - LS-C241389 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STUB1 / CHIP Antibody (aa243-271, AP) - LS-C241390 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STUB1 / CHIP Antibody (N-Terminus) - LS-C110748 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-STUB1 / CHIP Antibody (aa218-267) - LS-C80541 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-STUB1 / CHIP Antibody (aa243-271, FITC) - LS-C241392 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STUB1 / CHIP Antibody (aa243-271, PE) - LS-C241395 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STUB1 / CHIP Antibody - LS-C192424 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-STUB1 / CHIP Antibody (aa243-271, Azide-free, HRP) - LS-C248277 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STUB1 / CHIP Antibody - LS-C136962 from LifeSpan Bioscience Prices $255.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-STUB1 / CHIP Antibody (aa1-50) - LS-C288366 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-STUB1 / CHIP Antibody (aa243-271) - LS-C330185 from LifeSpan Bioscience Prices $435.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STUB1 / CHIP Antibody (Internal, clone EPR4448) - LS-C137950 from LifeSpan Bioscience Prices $480.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4448

Anti-STUB1 / CHIP Antibody (aa253-303) IHC-plus™ - LS-B11048 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-STUB1 / CHIP Antibody (aa253-303) IHC-plus™ - LS-B11567 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

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