VPS4A

Gene Symbol	VPS4A
Entrez Gene	27183
Alt Symbol	SKD1, SKD1A, SKD2, VPS4, VPS4-1
Species	Human
Gene Type	protein-coding
Description	vacuolar protein sorting 4 homolog A (S. cerevisiae)
Other Description	SKD1-homolog|hVPS4|vacuolar protein sorting factor 4A|vacuolar protein sorting-associated protein 4A|vacuolar sorting protein 4
Swissprots	Q9UN37 B2RCB7 Q8TF07 Q9Y582 Q9UI03
Accessions	AAG01470 EAW83261 EAW83262 EAW83263 EAW83264 Q9UN37 AF112215 AAF17203 AF132747 AAL75948 AF155740 AAD42971 AF159063 AAD49227 AF255952 AAK52408 AK000200 BAA91005 AK025850 AK315026 BAG37514 AL133634 CAB63758 BC013021 BC035121 AAH35121 BC047932 AAH47932 EU831747 ACE86581 NM_013245 NP_037377
Function	Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphory
Subcellular Location	Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Midbody. Note=Membrane-associated in the prevacuolar endosomal compartment. Localizes to the midbody of dividing cells, interaction with ZFYVE19/ANCHR mediates retention at midbody (PubMed:24814515). Localized in two distinct rings on either side of the Fleming body. {ECO:0000269|PubMed:24814515}.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:10637304, ECO:0000269|PubMed:11563910}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human VPS4a full length protein - ab162109 from Abcam Category Protein Source Wheat germ Species Human

VPS4A Antibody Blocking Peptide - LS-E19803 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human VPS4A Protein - H00027183-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

VPS4A Blocking Peptide - 33R-5392 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

VPS4A Blocking Peptide - 33R-10096 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

VPS4A - H00027183-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

VPS4A - H00027183-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

VPS4A fusion protein - ag5947 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

VPS4A fusion protein - Ag5592 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Vacuolar protein sorting-associated protein 4A(VPS4A) - CSB-YP891974HU CSB-EP891974HU CSB-BP891974HU CSB-MP891974HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

VPS4A - TP308099 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Vacuolar protein sorting-associated protein 4A(VPS4A) , Recombinant Protein - MBS1407501 from MyBioSource Category Protein Prices $1,965.00, $1,965.00, $2,430.00, $2,430.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

VPS4A-Blocking-Peptide-N-term - BP20724a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

VPS4A Peptide, Human - M34GP17325H from Creative Peptides Category Peptide Source Synthetic. Species Human

VPS4A Recombinant Protein Antigen - NBP2-57242PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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