| Gene Symbol |
MOGAT2
|
| Entrez Gene |
80168
|
| Alt Symbol |
DGAT2L5, MGAT2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
monoacylglycerol O-acyltransferase 2
|
| Other Description |
2-acylglycerol O-acyltransferase 2|acyl CoA:monoacylglycerol acyltransferase 2|acyl-CoA:monoacylglycerol acyltransferase 2|diacylglycerol O-acyltransferase candidate 5|diacylglycerol acyltransferase 2-like protein 5|hDC5|hMGAT2
|
| Swissprots |
Q86UH6 Q9H630 A8K7I3 Q3SYC2 Q3SYC1 Q6ZQZ2
|
| Accessions |
CBF67540 CBF90899 CBU92413 CBV04419 EAW74982 EAW74983 Q3SYC2 AK000245 AK026297 BAB15436 AK128620 BAC87534 AK291998 BAF84687 AY157608 AAO23672 BC103876 AAI03877 BC103877 AAI03878 BC103878 AAI03879 XM_011545267 XP_011543569 XR_950059 NM_025098 NP_079374
|
| Function |
Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. {ECO:0000269|PubMed:12621063}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:12621063}; Multi-pass membrane protein {ECO:0000269|PubMed:12621063}.
|
| Tissue Specificity |
Highly expressed in liver, small intestine, colon, stomach and kidney. {ECO:0000269|PubMed:12621063, ECO:0000269|PubMed:12824082}.
|
| Top Pathways |
Fat digestion and absorption, Glycerolipid metabolism
|