Gene Symbol | MOGAT2 |
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Entrez Gene | 80168 |
Alt Symbol | DGAT2L5, MGAT2 |
Species | Human |
Gene Type | protein-coding |
Description | monoacylglycerol O-acyltransferase 2 |
Other Description | 2-acylglycerol O-acyltransferase 2|acyl CoA:monoacylglycerol acyltransferase 2|acyl-CoA:monoacylglycerol acyltransferase 2|diacylglycerol O-acyltransferase candidate 5|diacylglycerol acyltransferase 2-like protein 5|hDC5|hMGAT2 |
Swissprots | Q86UH6 Q9H630 A8K7I3 Q3SYC2 Q3SYC1 Q6ZQZ2 |
Accessions | CBF67540 CBF90899 CBU92413 CBV04419 EAW74982 EAW74983 Q3SYC2 AK000245 AK026297 BAB15436 AK128620 BAC87534 AK291998 BAF84687 AY157608 AAO23672 BC103876 AAI03877 BC103877 AAI03878 BC103878 AAI03879 XM_011545267 XP_011543569 XR_950059 NM_025098 NP_079374 |
Function | Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. {ECO:0000269|PubMed:12621063}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12621063}; Multi-pass membrane protein {ECO:0000269|PubMed:12621063}. |
Tissue Specificity | Highly expressed in liver, small intestine, colon, stomach and kidney. {ECO:0000269|PubMed:12621063, ECO:0000269|PubMed:12824082}. |
Top Pathways | Fat digestion and absorption, Glycerolipid metabolism |
MGAT2 CRISPR/Cas9 KO Plasmid (h) - sc-406205 from Santa Cruz Biotechnology
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MGAT2 HDR Plasmid (h) - sc-406205-HDR from Santa Cruz Biotechnology
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MGAT2 Double Nickase Plasmid (h) - sc-406205-NIC from Santa Cruz Biotechnology
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MGAT2 Double Nickase Plasmid (h2) - sc-406205-NIC-2 from Santa Cruz Biotechnology
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MGAT2 CRISPR Activation Plasmid (h) - sc-406205-ACT from Santa Cruz Biotechnology
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MGAT2 CRISPR Activation Plasmid (h2) - sc-406205-ACT-2 from Santa Cruz Biotechnology
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MGAT2 Lentiviral Activation Particles (h) - sc-406205-LAC from Santa Cruz Biotechnology
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MGAT2 Lentiviral Activation Particles (h2) - sc-406205-LAC-2 from Santa Cruz Biotechnology
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MGAT2 siRNA (h) - sc-44468 from Santa Cruz Biotechnology
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MGAT2 shRNA Plasmid (h) - sc-44468-SH from Santa Cruz Biotechnology
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MGAT2 shRNA (h) Lentiviral Particles - sc-44468-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU123381 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14464 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14464 from Sigma-Aldrich
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MOGAT2 siRNA (Human) - CRJ2781 from Cohesion Biosciences
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shRNA set against Human MOGAT2 (NM_025098.2) - SHH343428 from Creative biogene
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Human MOGAT2 siRNA - orb273282 from Biorbyt
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MOGAT2 shRNA Plasmid (Human) - CHJ2781 from Cohesion Biosciences
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MOGAT2 miRNA 3'UTR clone - MiUTR1H-06379 from Creative biogene
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