Gene Symbol | RPS6KA6 |
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Entrez Gene | 27330 |
Alt Symbol | PP90RSK4, RSK4 |
Species | Human |
Gene Type | protein-coding |
Description | ribosomal protein S6 kinase, 90kDa, polypeptide 6 |
Other Description | 90 kDa ribosomal protein S6 kinase 6|RSK-4|S6K-alpha 6|S6K-alpha-6|p90-RSK 6|p90RSK6|ribosomal S6 kinase 4|ribosomal protein S6 kinase alpha-6 |
Swissprots | Q6FHX2 B2R854 Q9H4S6 B7ZL90 Q8WX28 Q9UK32 |
Accessions | CAJ32899 EAW98575 Q9UK32 AF184965 AAF13190 AK023104 AK026301 AK310346 AK313240 BAG36051 BC143647 BC143648 AAI43649 BC146380 AAI46381 BC148802 AAI48803 BQ448025 CR536566 CAG38803 XM_011530917 XP_011529219 XM_011530918 XP_011529220 XM_011530919 XP_011529221 XM_011530920 XP_011529222 NM_014496 NP_055311 |
Function | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:15632195}. Nucleus {ECO:0000269|PubMed:15632195}. Note=Predominantly cytosolic. |
Top Pathways | Long-term potentiation, Progesterone-mediated oocyte maturation, MAPK signaling pathway, Neurotrophin signaling pathway, Oocyte meiosis |
Rsk-4 CRISPR/Cas9 KO Plasmid (h) - sc-402383 from Santa Cruz Biotechnology
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Rsk-4 HDR Plasmid (h) - sc-402383-HDR from Santa Cruz Biotechnology
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Rsk-4 Double Nickase Plasmid (h) - sc-402383-NIC from Santa Cruz Biotechnology
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Rsk-4 Double Nickase Plasmid (h2) - sc-402383-NIC-2 from Santa Cruz Biotechnology
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Rsk-4 CRISPR Activation Plasmid (h) - sc-402383-ACT from Santa Cruz Biotechnology
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Rsk-4 CRISPR Activation Plasmid (h2) - sc-402383-ACT-2 from Santa Cruz Biotechnology
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Rsk-4 Lentiviral Activation Particles (h) - sc-402383-LAC from Santa Cruz Biotechnology
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Rsk-4 Lentiviral Activation Particles (h2) - sc-402383-LAC-2 from Santa Cruz Biotechnology
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Rsk-4 siRNA (h) - sc-39212 from Santa Cruz Biotechnology
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Rsk-4 shRNA Plasmid (h) - sc-39212-SH from Santa Cruz Biotechnology
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Rsk-4 shRNA (h) Lentiviral Particles - sc-39212-V from Santa Cruz Biotechnology
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RSK4 RNAi - H00027330-R02 from Novus Biologicals
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MISSION® esiRNA - EHU011261 from Sigma-Aldrich
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MISSION® esiRNA - EHU117521 from Sigma-Aldrich
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MISSION® siRNA - SIHK2021 from Sigma-Aldrich
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MISSION® siRNA - SIHK2019 from Sigma-Aldrich
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MISSION® siRNA - SIHK2020 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2400 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2400 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02024 from Sigma-Aldrich
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RPS6KA6 siRNA (Human) - CRH9081 from Cohesion Biosciences
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RPS6KA6 - MBS8232366 from MyBioSource
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shRNA set against Human Rps6ka6 (NM_014496.4) - SHH399596 from Creative biogene
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Human RPS6KA6 siRNA - orb269583 from Biorbyt
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RPS6KA6 shRNA Plasmid (Human) - CHH9081 from Cohesion Biosciences
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