VWF

Gene Symbol	VWF
Entrez Gene	7450
Alt Symbol	F8VWF, VWD
Species	Human
Gene Type	protein-coding
Description	von Willebrand factor
Other Description	coagulation factor VIII VWF
Swissprots	Q8TCE8 P04275 Q99806
Accessions	AAA61294 AAA61295 AAB59458 AEY75227 CAA29985 CBX54458 CCQ25771 CDI44165 EAW88814 EAW88815 EAW88816 EAW88817 EAW88818 P04275 AF086470 AK292122 BAF84811 AK297600 BAG59985 AK298097 BAG60382 AK301216 BAG62791 BC022258 AAH22258 BG951111 BQ898017 DB293903 GU014837 ACX32324 K03028 AAA61293 M10321 AAB59512 M17588 AAA65940 U81237 AAB39987 X02672 CAA26503 X04146 CAA27765 X04385 CAA27972 NM_000552 NP_000543
Function	Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
Subcellular Location	Secreted {ECO:0000269|PubMed:10961880}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:10961880}. Note=Localized to storage granules.
Tissue Specificity	Plasma.
Top Pathways	Focal adhesion, Complement and coagulation cascades, ECM-receptor interaction, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Von Willebrand Factor full length protein - ab152801 from Abcam Category Protein Source Wheat germ Species Human

Human Von Willebrand Factor full length protein - ab88533 from Abcam Category Protein Source Native Species Human

Human Von Willebrand Factor full length protein - ab185266 from Abcam Category Protein Source Native Species Human

Human Von Willebrand Factor full length protein - ab88555 from Abcam Category Protein Source Native Species Human

Von Willebrand Factor peptide - ab47296 from Abcam Category Peptide

Recombinant Human Von Willebrand Factor Protein - H00007450-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human vWF-A2, CF - 2764-WF-050 from R&D Systems Category Protein Source E. coli-derived, Asp1498-Val1665, with an N-terminal Met and 6-His tag

Von Willebrand Factor Ag Protein (OPMA04356) - OPMA04356 from Aviva Systems Biology Category Protein Prices $715.00 Sizes 100 µg Source Human Plasma

Human VWF protein - orb244628 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human vWF His tag protein - orb83288 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source CHO Species Human

VWF protein - 30C-CP4002U from Fitzgerald Category Protein Prices $622.80 Sizes 100 µg

VWF protein (Factor VIII Free) - 30C-CP4003U from Fitzgerald Category Protein Prices $622.80 Sizes 100 µg

Human vWA2 Protein - abx069694 from Abbexa Category Protein Source E.coli Species Human

VWF Protein - abx069979 from Abbexa Category Protein Source Human Plasma

von Willebrand factor (VWF) - H00007450-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

von Willebrand factor (VWF) - H00007450-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Von Willebrand Factor (vWF), Human - 20-7195 from ARP American Research Products Category Protein Prices $457.00 Sizes 50 µg Source E.coli Species Human

Von Willebrand Factor A Domain Containing Protein 2 (vWA2), Human - 20-7690 from ARP American Research Products Category Protein Prices $549.00 Sizes 50 µg Source E.coli Species Human

Recombinant Human Von Willebrand Factor - VWF-126H from Creative Biomart Category Protein Source E.coli .

Recombinant Human VWF, His tagged - VWF-894H from Creative Biomart Category Protein Source CHO Cells Species Human

Recombinant Human VWF protein, Met/His-tagged - VWF-2712H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human VWF, DDK-tagged - VWF-2713H from Creative Biomart Category Protein Source sf9 cells Species Human

Recombinant Human VWF, DDK-tagged - VWF-2714H from Creative Biomart Category Protein Source sf9 cells Species Human

Native Human von Willebrand Factor, Factor VIII Free - VWF-17H from Creative Biomart Category Protein Source Human plasma Species Human

Native Human Von Willebrand Factor - VWF-369H from Creative Biomart Category Protein Source Human plasma Species Human

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