| Gene Symbol |
FOXC1
|
| Entrez Gene |
2296
|
| Alt Symbol |
ARA, FKHL7, FREAC-3, FREAC3, IGDA, IHG1, IRID1, RIEG3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
forkhead box C1
|
| Other Description |
forkhead box C1 protein|forkhead box protein C1|forkhead, drosophila, homolog-like 7|forkhead-related activator 3|forkhead-related protein FKHL7|forkhead-related transcription factor 3|forkhead/winged helix-like transcription factor 7|myeloid factor-delta
|
| Swissprots |
Q9UP06 Q86UP7 Q9UDD0 Q12948 Q9NUE5 Q9BYM1
|
| Accessions |
AAC18081 AAC72915 AAP15181 ACS83750 AHI85954 EAW55074 Q12948 AK021858 BC134421 AAI34422 BC169306 AAI69306 BC169307 AAI69307 L12143 AAK13575 U13221 AAA92038 NM_001453 NP_001444
|
| Function |
Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'- GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye. {ECO:0000269|PubMed:17993506}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Expressed in all tissues and cell lines examined. {ECO:0000269|PubMed:8499623}.
|