Gene Symbol | FOXC1 |
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Entrez Gene | 2296 |
Alt Symbol | ARA, FKHL7, FREAC-3, FREAC3, IGDA, IHG1, IRID1, RIEG3 |
Species | Human |
Gene Type | protein-coding |
Description | forkhead box C1 |
Other Description | forkhead box C1 protein|forkhead box protein C1|forkhead, drosophila, homolog-like 7|forkhead-related activator 3|forkhead-related protein FKHL7|forkhead-related transcription factor 3|forkhead/winged helix-like transcription factor 7|myeloid factor-delta |
Swissprots | Q9UP06 Q86UP7 Q9UDD0 Q12948 Q9NUE5 Q9BYM1 |
Accessions | AAC18081 AAC72915 AAP15181 ACS83750 AHI85954 EAW55074 Q12948 AK021858 BC134421 AAI34422 BC169306 AAI69306 BC169307 AAI69307 L12143 AAK13575 U13221 AAA92038 NM_001453 NP_001444 |
Function | Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'- GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye. {ECO:0000269|PubMed:17993506}. |
Subcellular Location | Nucleus. |
Tissue Specificity | Expressed in all tissues and cell lines examined. {ECO:0000269|PubMed:8499623}. |
FOXC1 CRISPR/Cas9 KO Plasmid (h) - sc-403113 from Santa Cruz Biotechnology
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FOXC1 HDR Plasmid (h) - sc-403113-HDR from Santa Cruz Biotechnology
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FOXC1 Double Nickase Plasmid (h) - sc-403113-NIC from Santa Cruz Biotechnology
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FOXC1 Double Nickase Plasmid (h2) - sc-403113-NIC-2 from Santa Cruz Biotechnology
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FOXC1 CRISPR Activation Plasmid (h) - sc-403113-ACT from Santa Cruz Biotechnology
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FOXC1 CRISPR Activation Plasmid (h2) - sc-403113-ACT-2 from Santa Cruz Biotechnology
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FOXC1 Lentiviral Activation Particles (h) - sc-403113-LAC from Santa Cruz Biotechnology
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FOXC1 Lentiviral Activation Particles (h2) - sc-403113-LAC-2 from Santa Cruz Biotechnology
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FOXC1 siRNA (h) - sc-43766 from Santa Cruz Biotechnology
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FOXC1 shRNA Plasmid (h) - sc-43766-SH from Santa Cruz Biotechnology
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FOXC1 shRNA (h) Lentiviral Particles - sc-43766-V from Santa Cruz Biotechnology
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FoxC1 RNAi - H00002296-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN8879 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8879 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10366 from Sigma-Aldrich
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FOXC1 siRNA (Human) - CRH1603 from Cohesion Biosciences
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FOXC1 - MBS8234654 from MyBioSource
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FOXC1 CRISPR/Cas9 KO Plasmid (h2) - sc-403113-KO-2 from Santa Cruz Biotechnology
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FOXC1 HDR Plasmid (h2) - sc-403113-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human Foxc1 (NM_001453.2) - SHH296421 from Creative biogene
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shRNA set against Human FOXC1(NM_001453.2) - SHH065927 from Creative biogene
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FOXC1 shRNA Plasmid (Human) - CHH1603 from Cohesion Biosciences
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FOXC1 miRNA 3'UTR clone - MiUTR1H-03812 from Creative biogene
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