| Gene Symbol | TNFRSF10C |
|---|---|
| Entrez Gene | 8794 |
| Alt Symbol | CD263, DCR1, DCR1-TNFR, LIT, TRAIL-R3, TRAILR3, TRID |
| Species | Human |
| Gene Type | protein-coding |
| Description | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain |
| Other Description | TNF-related apoptosis-inducing ligand receptor 3|antagonist decoy receptor for TRAIL/Apo-2L|cytotoxic TRAIL receptor-3|decoy TRAIL receptor without death domain|decoy receptor 1|lymphocyte inhibitor of TRAIL|tumor necrosis factor receptor superfamily member 10C |
| Swissprots | Q08AS6 O14755 O14798 Q6UXM5 Q6FH98 |
| Accessions | AAM82564 CAT16333 CBA12840 EAW63638 O14798 AF012536 AAB67104 AF012629 AAB67110 AF014794 AAC05593 AF016267 AAB81181 AF020502 AAB71413 AF033854 AAB87506 AK298664 BAG60832 AK298718 BAH12853 AK313213 BAG36028 AY358281 AAQ88648 BC017852 AAH17852 BC125041 AAI25042 BC125042 AAI25043 BG545631 CR541857 CAG46655 DC380668 NM_003841 NP_003832 |
| Function | Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. |
| Subcellular Location | Cell membrane; Lipid-anchor, GPI-anchor. |
| Tissue Specificity | Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart. |
| Top Pathways | Cytokine-cytokine receptor interaction, Apoptosis, Natural killer cell mediated cytotoxicity, Measles, Influenza A |