| Gene Symbol |
CACYBP
|
| Entrez Gene |
27101
|
| Alt Symbol |
GIG5, PNAS-107, S100A6BP, SIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcyclin binding protein
|
| Other Description |
S100A6-binding protein|Siah-interacting protein (SIP)|calcyclin-binding protein|growth-inhibiting gene 5 protein|hCacyBP
|
| Swissprots |
B3KSF1 Q5R370 Q9HB71 Q5R371 O60666 B2ZWH2
|
| Accessions |
CAC22475 EAW90982 EAW90983 Q9HB71 AF057356 AAC21458 AF275803 AAG23817 AF314752 AAG34170 AK093425 BAG52713 AK294042 BAG57394 AK313278 BAG36086 AL035305 CAA22910 AW300675 AY423723 AAS00486 BC005975 AAH05975 BC022352 AAH22352 BC067823 AAH67823 BC078151 AAH78151 BQ432793 CA951015 NM_001007214 NP_001007215 NM_014412 NP_055227
|
| Function |
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). {ECO:0000269|PubMed:16085652}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12895292}. Cytoplasm {ECO:0000269|PubMed:12895292}. Note=Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.
|
| Top Pathways |
Wnt signaling pathway
|