Gene Symbol | CACYBP |
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Entrez Gene | 27101 |
Alt Symbol | GIG5, PNAS-107, S100A6BP, SIP |
Species | Human |
Gene Type | protein-coding |
Description | calcyclin binding protein |
Other Description | S100A6-binding protein|Siah-interacting protein (SIP)|calcyclin-binding protein|growth-inhibiting gene 5 protein|hCacyBP |
Swissprots | B3KSF1 Q5R370 Q9HB71 Q5R371 O60666 B2ZWH2 |
Accessions | CAC22475 EAW90982 EAW90983 Q9HB71 AF057356 AAC21458 AF275803 AAG23817 AF314752 AAG34170 AK093425 BAG52713 AK294042 BAG57394 AK313278 BAG36086 AL035305 CAA22910 AW300675 AY423723 AAS00486 BC005975 AAH05975 BC022352 AAH22352 BC067823 AAH67823 BC078151 AAH78151 BQ432793 CA951015 NM_001007214 NP_001007215 NM_014412 NP_055227 |
Function | May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). {ECO:0000269|PubMed:16085652}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:12895292}. Cytoplasm {ECO:0000269|PubMed:12895292}. Note=Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated. |
Top Pathways | Wnt signaling pathway |
Human SIAH Interacting Protein peptide - ab23014 from Abcam
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Human SIAH Interacting Protein protein fragment - ab95489 from Abcam
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CACYBP Antibody Blocking Peptide - LS-E18451 from LifeSpan Bioscience
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CACYBP Recombinant Protein - H00027101-P01 from Novus Biologicals
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Recombinant Human CACYBP Protein - NBP1-44443 from Novus Biologicals
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CACYBP Protein (OPPA02267) - OPPA02267 from Aviva Systems Biology
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Human Calcyclin Binding protein - orb80974 from Biorbyt
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CACYBP Blocking Peptide - 33R-3089 from Fitzgerald
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CACYBP protein (His tag) - 80R-1330 from Fitzgerald
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CACYBP (1-185, His-tag) - AR09476PU-L from Acris Antibodies
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CACYBP (1-185, His-tag) - AR09476PU-N from Acris Antibodies
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CACYBP - H00027101-P01-10 from Acris Antibodies
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CACYBP - H00027101-P01-25 from Acris Antibodies
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CACYBP, 1-185aa, Human, His tag, E.coli - 01-1836 from ARP American Research Products
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CACYBP fusion protein - Ag2340 from Proteintech Group
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CACYBP Human - PRPS-838 from NeoScientific
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Recombinant Human Calcyclin Binding Protein - BP001838-PRO-831 from Syd Labs
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CACYBP, 1-185aa, Recombinant Protein - GWB-P1472C from Genway Biotech
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CACYBP Human Protein - GWB-BSP408 from Genway Biotech
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Recombinant Human Calcyclin Binding Protein, His-tagged - CACYBP-54H from Creative Biomart
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Recombinant Human Calcyclin Binding Protein - CACYBP-2533H from Creative Biomart
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Recombinant Human CACYBP, His-tagged - CACYBP-29815TH from Creative Biomart
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Recombinant Human CACYBP, His-tagged - CACYBP-31403TH from Creative Biomart
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Recombinant Human CACYBP, GST-tagged - CACYBP-10648H from Creative Biomart
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CACYBP 1-185aa - CMB-399 from Reagent Proteins
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